Rabbit polyclonal FBXW11 antibody (A7784)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FBXW11 antibody (A7784)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal FBXW11 antibody.

Alternative names:

Check alternative names for the antibody

Expand

Hos antibody, BTRC2 antibody, FBW1B antibody, Fbw11 antibody, BTRCP2 antibody, FBXW1B antibody
beta Transducin Repeat Containing Protein 2 antibody|BTRC2 antibody|BTRCP2 antibody|F-box and WD repeats protein beta-TrCP2 antibody|F-box and WD-40 Domain Protein 1B antibody|F-box Protein FBW1B antibody|F-box/WD repeat-containing protein 11 antibody|F-box/WD repeat-containing protein 1B antibody|FBW1B antibody|FBW1B_HUMAN antibody|FBXW11 antibody|FBXW1B antibody|Homologous to Slimb protein antibody|HOS antibody|Anti-beta TRCP2 antibody (ab154070)

SCBT cat No: sc-166492|

Name

Rabbit polyclonal FBXW11 antibody

Catalogue No.

A7784

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FBXW11

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 62kDa/Observed: Refer to figures

Formulation

FBXW11 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FBXW11 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

Hos antibody, BTRC2 antibody, FBW1B antibody, Fbw11 antibody, BTRCP2 antibody, FBXW1B antibody

Database links

Human UniProt/Swiss-Prot:Q9UKB1

Protein names

Hos, BTRC2, FBW1B, Fbw11, BTRCP2, FBXW1B

Protein function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis . Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

Protein sequence and domain

The N-terminal D domain mediates homodimerization.Contains 1 F-box domain.; Contains 7 WD repeats.

Protein cellular localization

Cytoplasm . Nucleus .

Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.

Note

AntibodyPlus can customize FBXW11 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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