Rabbit polyclonal FCGR3A antibody (A2552)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FCGR3A antibody (A2552)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CD16 antibody, FCG3 antibody, CD16A antibody, FCGR3 antibody, IGFR3 antibody, FCR-10 antibody, FCRIII antibody, FCGRIII antibody, FCRIIIA antibody
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SCBT cat No: sc-70548|sc-19620|sc-52376|sc-65294|sc-20052|sc-19594|sc-20627|sc-51524|sc-51525|sc-19357|sc-58962|sc-68910|

Name

Rabbit polyclonal FCGR3A antibody

Catalogue No.

A2552

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human FCGR3A

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 29kDa/Observed: Refer to Figures

Formulation

FCGR3A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FCGR3A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CD16 antibody, FCG3 antibody, CD16A antibody, FCGR3 antibody, IGFR3 antibody, FCR-10 antibody, FCRIII antibody, FCGRIII antibody, FCRIIIA antibody

Database links

Human UniProt/Swiss-Prot:P08637

Protein names

CD16, FCG3, CD16A, FCGR3, IGFR3, FCR-10, FCRIII, FCGRIII, FCRIIIA

Protein function

Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.

Protein tissue specificity

Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.

Protein sequence and domain

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Protein post-translational modifications

Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.; The soluble form is produced by a proteolytic cleavage.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Secreted. Note: Exists also as a soluble receptor.

Background

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Lymphocyte Signaling>CD16
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize FCGR3A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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