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Rabbit polyclonal FCN1 antibody (A6587)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal FCN1 antibody.
Check alternative names for the antibodyExpand
Collagen/fibrinogen domain containing protein 1 antibody|Collagen/fibrinogen domain-containing protein 1 antibody|Fcn1 antibody|FCN1_HUMAN antibody|FCNM antibody|ficolin (collagen/fibrinogen domain containing) 1 antibody|Ficolin 1 antibody|Ficolin A antibody|Ficolin alpha antibody|Ficolin-1 antibody|Ficolin-A antibody|Ficolin-alpha antibody|M ficolin antibody|M-ficolin antibody|Anti-FCN1 antibody (ab70814)
SCBT cat No: sc-80486|sc-168519|
Rabbit polyclonal FCN1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human FCN1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 35kDa/Observed: Refer to figures
FCN1 antibody was tube-contained.
FCN1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 . Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.
|Protein tissue specificity|| |
Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes.
|Protein sequence and domain|| |
The fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates and tethering to the cell surface in monocytes and granulocytes. The domain undergoes a conformational switch at pH under 6.2, and looses its carbohydrate-binding ability.Belongs to the ficolin lectin family.; Contains 1 collagen-like domain.; Contains 1 fibrinogen C-terminal domain.
|Protein cellular localization|| |
Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Note: Found on the monocyte and granulocyte surface .
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.
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|Product type|| |
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