Rabbit polyclonal FCN1 antibody (A6587)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FCN1 antibody (A6587)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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FCNM antibody
Collagen/fibrinogen domain containing protein 1 antibody|Collagen/fibrinogen domain-containing protein 1 antibody|Fcn1 antibody|FCN1_HUMAN antibody|FCNM antibody|ficolin (collagen/fibrinogen domain containing) 1 antibody|Ficolin 1 antibody|Ficolin A antibody|Ficolin alpha antibody|Ficolin-1 antibody|Ficolin-A antibody|Ficolin-alpha antibody|M ficolin antibody|M-ficolin antibody|Anti-FCN1 antibody (ab70814)

SCBT cat No: sc-80486|sc-168519|

Name

Rabbit polyclonal FCN1 antibody

Catalogue No.

A6587

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FCN1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 35kDa/Observed: Refer to figures

Formulation

FCN1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FCN1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FCNM antibody

Database links

Human UniProt/Swiss-Prot:O00602

Protein names

FCNM

Protein function

Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 . Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.

Protein tissue specificity

Peripheral blood leukocytes, monocytes and granulocytes. Also detected in spleen, lung, and thymus, may be due to the presence of tissue macrophages or trapped blood in these tissues. Not detected on lymphocytes.

Protein sequence and domain

The fibrinogen C-terminal domain mediates calcium-dependent binding to carbohydrates and tethering to the cell surface in monocytes and granulocytes. The domain undergoes a conformational switch at pH under 6.2, and looses its carbohydrate-binding ability.Belongs to the ficolin lectin family.; Contains 1 collagen-like domain.; Contains 1 fibrinogen C-terminal domain.

Protein cellular localization

Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Note: Found on the monocyte and granulocyte surface .

Background

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.

Note

AntibodyPlus can customize FCN1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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