Rabbit Polyclonal FER antibody (A9687)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal FER antibody (A9687)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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FerT antibody; TYK3 antibody; Pe1Fe3 antibody; Pe1Fe6 antibody; PPP1R74 antibody; Pe1Fe10 antibody; Pe1Fe13
c FER antibody|FER antibody|p94 FER antibody|p94-FER antibody|Pe1Fe10 antibody|Pe1Fe13 antibody|Pe1Fe3 antibody|Pe1Fe6 antibody|Phosphoprotein NCP94 antibody|PPP1R74 antibody|Protein phosphatase 1 regulatory subunit 74 antibody|Proto oncogene tyrosine protein kinase FER antibody|Proto-oncogene c-Fer antibody|TYK3 antibody|Tyrosine kinase 3 antibody|Tyrosine-protein kinase Fer antibody|Anti-FER antibody [EP1842Y] (ab52479)

SCBT cat No: sc-81272|sc-81708|sc-81461|sc-390484|sc-28771|

Name

Rabbit Polyclonal FER antibody

Catalogue No.

A9687

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FER

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

95kDa

Formulation

FER antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FerT antibody; TYK3 antibody; Pe1Fe3 antibody; Pe1Fe6 antibody; PPP1R74 antibody; Pe1Fe10 antibody; Pe1Fe13

Protein names

FerT; TYK3; Pe1Fe3; Pe1Fe6; PPP1R74; Pe1Fe10; Pe1Fe13

Protein function

Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.

Protein tissue specificity

Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.

Protein sequence and domain

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.; Contains 1 F-BAR domain.; Contains 1 protein kinase domain.; Contains 1 SH2 domain. The coiled coil domains mediate homooligomerization and are required for location at microtubules.; The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes.

Protein post-translational modifications

Autophosphorylated.; Polyubiquitinated; this leads to proteasomal degradation.

Protein cellular localization

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.

Background

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Kinases-and-Phosphatases/">Kinases and Phosphatases</a>><a href="http://antibodyplus.com/product-tag/Fer/">Fer</a><br><a href="http://antibodyplus.com/product-tag/Kinases-and-Phosphatases/"&gt; (View all antibody categories related to Kinases and Phosphatases)</a>

Note

AntibodyPlus can customize FER antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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