Rabbit polyclonal FES antibody (A2578)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FES antibody (A2578)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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FPS antibody
c-fes/fps protein antibody|cFES antibody|Feline sarcoma (Snyder Theilen) viral (v fes)/Fujinami avian sarcoma (PRCII) viral (v fps) oncogene homolog antibody|feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami antibody|Feline sarcoma oncogene antibody|Feline sarcoma/Fujinami avian sarcoma oncogene homolog antibody|fes antibody|FES proto oncogene, tyrosine kinase antibody|FES_HUMAN antibody|FPS antibody|Oncogene FES antibody|Oncogene FES feline sarcoma virus antibody|P93c fes antibody|Proto oncogene tyrosine protein kinase Fes/Fps antibody|Proto-oncogene c-Fes antibody|Proto-oncogene c-Fps antibody|proto-oncogene tyrosine-protein kinase Fes/Fps antibody|Tyrosine-protein kinase Fes/Fps antibody|Anti-FES antibody [EPR3230(2)] (ab108418)

SCBT cat No: sc-81704|sc-81706|sc-7670|sc-377179|sc-166371|sc-25415|sc-7671|

Name

Rabbit polyclonal FES antibody

Catalogue No.

A2578

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FES

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 93kDa/Observed: Refer to Figures

Formulation

FES antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FES antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FPS antibody

Database links

Human UniProt/Swiss-Prot:P07332

Protein names

FPS

Protein function

Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.

Protein tissue specificity

Widely expressed. Detected in adult colon epithelium.

Protein sequence and domain

The coiled coil domains are important for regulating the kinase activity. They mediate homooligomerization and probably also interaction with other proteins.; The N-terminal region including the first coiled coil domain mediates interaction with phosphoinositide-containing membranes.Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.; Contains 1 F-BAR domain.; Contains 1 protein kinase domain.; Contains 1 SH2 domain.

Protein post-translational modifications

Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK.

Protein cellular localization

Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note: Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.

Background

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.

Research area

All research areas>Kinases and Phosphatases>Fes
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize FES antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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