Rabbit polyclonal FGD4 antibody (A8596)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FGD4 antibody (A8596)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal FGD4 antibody.

Alternative names:

Check alternative names for the antibody

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9030023J02Rik antibody|Fgd4 antibody|FGD4_HUMAN antibody|FLJ34370 antibody|FLJ42663 antibody|FRABP antibody|FYVE antibody|FYVE, RhoGEF and PH domain containing 4 antibody|MGC57222 antibody|RhoGEF and PH domain-containing protein 4 antibody|ZFYVE6 antibody|Zinc finger FYVE domain containing protein 6 antibody|Zinc finger FYVE domain-containing protein 6 antibody|Anti-FGD4 antibody (ab97785)

SCBT cat No: sc-366617|sc-8596|

Name

Rabbit polyclonal FGD4 antibody

Catalogue No.

A8596

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FGD4

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 87kDa/Observed: Refer to figures

Formulation

FGD4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FGD4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:Q96M96

Protein function

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity).

Protein tissue specificity

Expressed in different tissues, including brain, cerebellum, peripheral nerve, skeletal muscle, heart, uterus, placenta and testis.

Protein sequence and domain

The part of the protein spanning the actin filament-binding domain together with the DH domain and the first PH domain is necessary and sufficient for microspike formation. Activation of MAPK8 requires the presence of all domains with the exception of the actin filament-binding domain (By similarity).Contains 1 DH (DBL-homology) domain.; Contains 1 FYVE-type zinc finger.; Contains 2 PH domains.

Protein cellular localization

Cytoplasm, cytoskeleton . Cell projection, filopodium . Note: Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity).

Background

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

Note

AntibodyPlus can customize FGD4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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