Rabbit polyclonal FGF2 antibody (A0235)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FGF2 antibody (A0235)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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FGF2 antibody,BFGF antibody,FGFB antibody,HBGF-2 antibody
Basic fibroblast growth factor antibody|Basic fibroblast growth factor bFGF antibody|BFGF antibody|FGF 2 antibody|FGF B antibody|FGF-2 antibody|Fgf2 antibody|FGF2 basic antibody|FGF2_HUMAN antibody|FGFB antibody|Fibroblast growth factor 2 (basic) antibody|Fibroblast growth factor 2 antibody|Fibroblast growth factor, basic antibody|HBGF 2 antibody|HBGF-2 antibody|HBGF2 antibody|HBGH 2 antibody|HBGH2 antibody|Heparin binding growth factor 2 precursor antibody|Heparin-binding growth factor 2 antibody|Prostatropin antibody|Anti-FGF2 antibody (ab8880)

SCBT cat No: sc-79|sc-136255|sc-271847|sc-74413|sc-1360|sc-74412|sc-365106|sc-7911|sc-1390|

Name

Rabbit polyclonal FGF2 antibody

Catalogue No.

A0235

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human FGF2

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 21kDa/Observed: Refer to Figures

Formulation

FGF2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FGF2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FGF2 antibody,BFGF antibody,FGFB antibody,HBGF-2 antibody

Database links

Human UniProt/Swiss-Prot:P09038

Protein names

FGF2,BFGF,FGFB,HBGF-2

Protein function

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis .

Protein tissue specificity

Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.

Protein sequence and domain

Belongs to the heparin-binding growth factors family.

Protein post-translational modifications

Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.; Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.

Protein cellular localization

Secreted. Nucleus. Note: Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.

Background

Fibroblast growth factors are a family of broad-spectrum growth factors influencing a plethora of cellular activities. The interaction of at least 23 ligands, 4 receptors and multiple coreceptors provides a dramatic complexity to a signaling system capable of effecting a multitude of responses (1,2). Basic fibroblast growth factor (bFGF or FGF2), initially identified as a mitogen with prominent angiogenic properties, is now recognized as a multifunctional growth factor (3). It is clear that bFGF produces its biological effects in target cells by signaling through cell-surface FGF receptors. bFGF binds to all four FGF receptors. Ligand binding induces receptor dimerization and autophosphorylation, allowing binding and activation of cytoplasmic downstream target proteins, including FRS-2, PLC and Crk (4,5). The FGF signaling pathway appears to play a significant role not only in normal cell growth regulation but also in tumor development and progression (6).Acidic FGF (aFGF or FGF1) is another extensively investigated protein of the FGF family. aFGF shares 55% DNA sequence homology with bFGF. These two growth factors are ubiquitously expressed and exhibit a wide spectrum of similiar biological activities with quantitative differences likely due to variation in receptor affinity or binding (7).

Research area

All research areas>Growth Factors and Hormones>FGF
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize FGF2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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