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Rabbit polyclonal FGG antibody (A5642)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal FGG antibody.
Check alternative names for the antibodyExpand
FGG antibody|FIBG_HUMAN antibody|Fibrinogen gamma chain antibody|Fibrinogen gamma polypeptide antibody|fibrinogen gamma-b chain antibody|Anti-Fibrinogen gamma chain antibody [5A6] (ab119948)
SCBT cat No: sc-81620|sc-133157|sc-18032|sc-133226|sc-133156|sc-33582|
Rabbit polyclonal FGG antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human FGG
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 51kDa/Observed: Refer to Figures
FGG antibody was tube-contained.
FGG antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
|Protein tissue specificity|| |
Detected in blood plasma (at protein level).
|Protein sequence and domain|| |
A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.Contains 1 fibrinogen C-terminal domain.
|Protein post-translational modifications|| |
Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.; Sulfation of C-terminal tyrosines increases affinity for thrombin.
|Protein cellular localization|| |
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
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|Product type|| |
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