Rabbit polyclonal FHIT antibody (A1196)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FHIT antibody (A1196)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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FHIT antibody,AP3Aase antibody,FRA3B antibody
AP3A hydrolase antibody|AP3A hydrolase fragile site 3p14.2 antibody|AP3Aase antibody|Bis 5′ adenosyl triphosphatase antibody|Bis(5′ adenosyl) triphosphatase antibody|Diadenosine 5′ 5”’ P1 P3 triphosphate hydrolase antibody|Dinucleosidetriphosphatase antibody|FRA 3B antibody|FRA3B antibody|Fragile histidine triad antibody|Fragile histidine triad gene antibody|Fragile histidine triad protein antibody|Tumor suppressor protein antibody|Anti-FHIT antibody (ab53074)

SCBT cat No: sc-271621|sc-292538|

Name

Rabbit polyclonal FHIT antibody

Catalogue No.

A1196

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FHIT

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 17kDa/Observed: Refer to Figures

Formulation

FHIT antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FHIT antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FHIT antibody,AP3Aase antibody,FRA3B antibody

Database links

Human UniProt/Swiss-Prot:P49789

Protein names

FHIT,AP3Aase,FRA3B

Protein function

Cleaves P(1)-P(3)-bis(5′-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5′-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5′-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.

Protein tissue specificity

Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines.

Protein sequence and domain

Contains 1 HIT domain.

Protein post-translational modifications

Phosphorylation at Tyr-114 by SRC is required for induction of apoptosis.

Protein cellular localization

Cytoplasm. Mitochondrion. Nucleus.

Background

This gene, a member of the histidine triad gene family, encodes a diadenosine 5′,5”’-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Research area

All research areas>Tumor Suppressor/Apoptosis>Fhit
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize FHIT antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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