Rabbit polyclonal FIP1L1 antibody (A7138)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FIP1L1 antibody (A7138)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal FIP1L1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

Rhe antibody, FIP1 antibody, hFip1 antibody
DKFZp586K0717 antibody|Factor interacting with PAP antibody|FIP1 antibody|FIP1 like 1 (S cerevisiae) antibody|FIP1 like 1 antibody|FLJ33619 antibody|hFip 1 antibody|hFip1 antibody|Pre mRNA 3 end processing factor FIP1 antibody|Rearranged in hypereosinophilia antibody|RHE antibody|Anti-FIP1L1 antibody (ab80272)

SCBT cat No: sc-398392|sc-104243|

Name

Rabbit polyclonal FIP1L1 antibody

Catalogue No.

A7138

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FIP1L1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 67kDa/Observed: Refer to figures

Formulation

FIP1L1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FIP1L1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

Rhe antibody, FIP1 antibody, hFip1 antibody

Database links

Human UniProt/Swiss-Prot:Q6UN15

Protein names

Rhe, FIP1, hFip1

Protein function

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3′-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.

Protein sequence and domain

Belongs to the FIP1 family.

Protein cellular localization

Nucleus.

Background

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3′ end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Note

AntibodyPlus can customize FIP1L1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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