Rabbit polyclonal FKBP4 antibody (A5643)


Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FKBP4 antibody (A5643)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal FKBP4 antibody.

Alternative names:

Check alternative names for the antibody


HBI antibody, p52 antibody, Hsp56 antibody, FKBP51 antibody, FKBP52 antibody, FKBP59 antibody, PPIase antibody
51 kDa FK506-binding protein antibody|52 kDa FK506 binding protein antibody|52 kDa FK506-binding protein antibody|52 kDa FKBP antibody|59 kDa immunophilin antibody|FK506 binding protein 4 antibody|FK506-binding protein 4 antibody|FKBP 4 antibody|FKBP 52 antibody|FKBP 59 antibody|FKBP-4 antibody|FKBP-52 antibody|FKBP4 antibody|FKBP4_HUMAN antibody|FKBP51 antibody|FKBP52 protein antibody|FKBP59 antibody|HBI antibody|Hsp 56 antibody|HSP binding immunophilin antibody|HSP-binding immunophilin antibody|Hsp56 antibody|Immunophilin FKBP52 antibody|N-terminally processed antibody|p52 antibody|p59 antibody|p59 protein antibody|Peptidyl prolyl cis trans isomerase antibody|Peptidyl-prolyl cis-trans isomerase FKBP4 antibody|Peptidylprolyl cis trans isomerase antibody|PPIase antibody|PPIase FKBP4 antibody|Rotamase antibody|T cell FK506 binding protein 59kD antibody|Anti-FKBP52 antibody [EPR6618] (ab129097)

SCBT cat No: sc-100758|sc-1803|


Rabbit polyclonal FKBP4 antibody

Catalogue No.



Human, Mouse, Rat


Recombinant protein of human FKBP4





Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200







Molecular weight

Predicted: 51kDa/Observed: Refer to Figures


FKBP4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


FKBP4 antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HBI antibody, p52 antibody, Hsp56 antibody, FKBP51 antibody, FKBP52 antibody, FKBP59 antibody, PPIase antibody

Database links

Human UniProt/Swiss-Prot:Q02790

Protein names

HBI, p52, Hsp56, FKBP51, FKBP52, FKBP59, PPIase

Protein function

Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.

Protein tissue specificity

Widely expressed.

Protein sequence and domain

The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA).; The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.; The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.; The TPR repeats mediate mitochondrial localization.Contains 2 PPIase FKBP-type domains.; Contains 3 TPR repeats.

Protein post-translational modifications

Phosphorylation by CK2 results in loss of HSP90 binding activity.

Protein cellular localization

Cytoplasm, cytosol . Mitochondrion . Nucleus . Cytoplasm, cytoskeleton . Cell projection, axon . Note: Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor . Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity).


The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.

Research area

All research areas>Signaling Intermediates>HSP
(View all antibody categories related to Signaling Intermediates)


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Product type

Primary antibody


ABclonal Inc.


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