Rabbit polyclonal FKBP4 antibody (A5643)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FKBP4 antibody (A5643)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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HBI antibody, p52 antibody, Hsp56 antibody, FKBP51 antibody, FKBP52 antibody, FKBP59 antibody, PPIase antibody
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SCBT cat No: sc-100758|sc-1803|

Name

Rabbit polyclonal FKBP4 antibody

Catalogue No.

A5643

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FKBP4

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 51kDa/Observed: Refer to Figures

Formulation

FKBP4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FKBP4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HBI antibody, p52 antibody, Hsp56 antibody, FKBP51 antibody, FKBP52 antibody, FKBP59 antibody, PPIase antibody

Database links

Human UniProt/Swiss-Prot:Q02790

Protein names

HBI, p52, Hsp56, FKBP51, FKBP52, FKBP59, PPIase

Protein function

Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.

Protein tissue specificity

Widely expressed.

Protein sequence and domain

The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA).; The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.; The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400.; The TPR repeats mediate mitochondrial localization.Contains 2 PPIase FKBP-type domains.; Contains 3 TPR repeats.

Protein post-translational modifications

Phosphorylation by CK2 results in loss of HSP90 binding activity.

Protein cellular localization

Cytoplasm, cytosol . Mitochondrion . Nucleus . Cytoplasm, cytoskeleton . Cell projection, axon . Note: Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor . Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity).

Background

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene.

Research area

All research areas>Signaling Intermediates>HSP
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize FKBP4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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