Rabbit polyclonal FKBP6 antibody (A7013)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FKBP6 antibody (A7013)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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FKBP36 antibody
36 kDa FK506 binding protein antibody|36 kDa FK506-binding protein antibody|36 kDa FKBP antibody|EC 5.2.1.8 antibody|FK506 binding protein 6 antibody|FK506-binding protein 6 antibody|FKBP 36 antibody|FKBP-36 antibody|FKBP-6 antibody|FKBP36 antibody|fkbp6 antibody|FKBP6_HUMAN antibody|Immunophilin FKBP36 antibody|Peptidyl prolyl cis trans isomerase antibody|Peptidyl-prolyl cis-trans isomerase FKBP6 antibody|PPIase antibody|PPIase FKBP6 antibody|Rotamase antibody|Anti-FKBP6 antibody [EPR3673] (ab108419)

SCBT cat No: sc-517136|sc-104249|

Name

Rabbit polyclonal FKBP6 antibody

Catalogue No.

A7013

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FKBP6

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 37kDa/Observed: Refer to figures

Formulation

FKBP6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FKBP6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FKBP36 antibody

Database links

Human UniProt/Swiss-Prot:O75344

Protein names

FKBP36

Protein function

Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).

Protein tissue specificity

Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.

Protein sequence and domain

Belongs to the FKBP6 family.; Contains 1 PPIase FKBP-type domain.; Contains 3 TPR repeats.

Protein cellular localization

Cytoplasm, cytosol . Nucleus . Chromosome . Note: Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (By similarity).

Background

The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants.

Note

AntibodyPlus can customize FKBP6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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