Rabbit polyclonal FKBP8 antibody (A7085)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FKBP8 antibody (A7085)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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FKBP38 antibody, FKBPr38 antibody
38 kDa FK506-binding protein antibody|38 kDa FKBP antibody|38kDa antibody|FK506 binding protein 8 antibody|FK506 binding protein 8, 38kDa antibody|FK506 binding protein, 38kDa antibody|FK506-binding protein 8 antibody|FKBP 38 antibody|FKBP-38 antibody|FKBP-8 antibody|Fkbp8 antibody|FKBP8_HUMAN antibody|FKBPR38 antibody|hFKBP38 antibody|Peptidyl-prolyl cis-trans isomerase FKBP8 antibody|PPIase FKBP8 antibody|Rotamase antibody|Sam11 antibody|Anti-FKBP38 antibody (ab24450)

SCBT cat No: sc-166607|sc-66894|

Name

Rabbit polyclonal FKBP8 antibody

Catalogue No.

A7085

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FKBP8

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to figures

Formulation

FKBP8 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FKBP8 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FKBP38 antibody, FKBPr38 antibody

Database links

Human UniProt/Swiss-Prot:Q14318

Protein names

FKBP38, FKBPr38

Protein function

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Protein tissue specificity

Widely expressed. Highest levels seen in the brain. Highly abundant in the retina.

Protein sequence and domain

Contains 1 PPIase FKBP-type domain.; Contains 3 TPR repeats.

Protein post-translational modifications

Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

Protein cellular localization

Mitochondrion . Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side .; Isoform 1: Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side .; Isoform 3: Mitochondrion membrane ; Single-pass membrane protein; Cytoplasmic side .

Background

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.

Note

AntibodyPlus can customize FKBP8 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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