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Rabbit polyclonal FKRP antibody (A10194)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:1000 – 1:3000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal FKRP antibody.
Check alternative names for the antibodyExpand
Fkrp antibody|LGMD2I antibody|MDC1C antibody|MGC2991 antibody|Anti-FKRP antibody (ab65243)
SCBT cat No: sc-48503|sc-374642|sc-48506|
Rabbit polyclonal FKRP antibody
|Catalogue No.|| |
Recombinant protein of human FKRP
|Recommended dilution|| |
WB 1:1000 – 1:3000
|Molecular weight|| |
Predicted: 55kDa/Observed: Refer to figures
FKRP antibody was tube-contained.
FKRP antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Transferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.
|Protein tissue specificity|| |
Expressed predominantly in skeletal muscle, placenta, and heart and relatively weakly in brain, lung, liver kidney and pancreas.
|Protein sequence and domain|| |
Belongs to the LicD transferase family.
|Protein post-translational modifications|| |
|Protein cellular localization|| |
Golgi apparatus membrane ; Single-pass type II membrane protein. Secreted. Cell membrane, sarcolemma . Rough endoplasmic reticulum. Note: According to some studies the N-terminal hydrophobic domain is cleaved after translocation to the Golgi apparatus and the protein is secreted. Localization at the cell membrane may require the presence of dystroglycan. At the Golgi apparatus localizes to the middle-to-trans-cisternae, as assessed by MG160 colocalization. Detected in rough endoplasmic reticulum in myocytes. In general, mutants associated with severe clinical phenotypes are retained within the endoplasmic reticulum.
This gene encodes a protein which is targeted to the medial Golgi apparatus and is necessary for posttranslational modification of dystroglycan. Mutations in this gene have been associated with congenital muscular dystrophy, mental retardation, and cerebellar cysts. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2008]
AntibodyPlus can customize FKRP antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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