Rabbit polyclonal FOXM1 antibody (A2493)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FOXM1 antibody (A2493)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

FKHL16 antibody, FOXM1B antibody, HFH-11 antibody, HFH11 antibody, HNF-3 antibody, INS-1 antibody, MPHOSPH2 antibody, MPP-2 antibody, MPP2 antibody, PIG29 antibody, TGT3 antibody, TRIDENT antibody
FKHL16 antibody|FOX M1 antibody|Foxm1 antibody|FOXM1_HUMAN antibody|FOXM1B antibody|Hepatocyte nuclear factor 3 forkhead homolog 11 antibody|HFH-11 antibody|HFH11 antibody|HNF-3/fork-head homolog 11 antibody|HNF3 antibody|INS1 antibody|M phase phosphoprotein 2 antibody|M-phase phosphoprotein 2 antibody|MPHOSPH2 antibody|MPM-2 reactive phosphoprotein 2 antibody|MPP2 antibody|PIG29 antibody|TGT3 antibody|Transcription factor Trident antibody|Trident antibody|WIN antibody|Winged-helix factor from INS-1 cells antibody|Winged-helix factor from INS1 cells antibody|Anti-FOXM1 antibody (ab175798)

SCBT cat No: sc-271746|sc-502|sc-166709|sc-376621|sc-376620|sc-376471|sc-501|sc-32855|sc-13016|sc-500|

Name

Rabbit polyclonal FOXM1 antibody

Catalogue No.

A2493

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FOXM1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 83kDa/Observed: Refer to Figures

Formulation

FOXM1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FOXM1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FKHL16 antibody, FOXM1B antibody, HFH-11 antibody, HFH11 antibody, HNF-3 antibody, INS-1 antibody, MPHOSPH2 antibody, MPP-2 antibody, MPP2 antibody, PIG29 antibody, TGT3 antibody, TRIDENT antibody

Database links

Human UniProt/Swiss-Prot:Q08050

Protein names

FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TGT3, TRIDENT

Protein function

Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.

Protein tissue specificity

Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.

Protein sequence and domain

Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4.Contains 1 fork-head DNA-binding domain.

Protein post-translational modifications

Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators.

Protein cellular localization

Nucleus.

Background

Forkhead box M1 (FoxM1) is a forkhead box family transcription factor that regulates a number of genes throughout the cell cycle to help control DNA replication, mitosis and cell proliferation. FoxM1 expression increases during G1 and S and reaches maximum levels in G2/M (1-3). Nuclear translocation occurs just before entry into G2/M and is associated with FoxM1 phosphorylation (4). Phosphorylation of FoxM1 by MAPK (Ser331 Ser704), Cyclin/Cdk (Thr600, Thr611, Thr672), Plk1 (Ser715, Ser724), and Chk2 (Ser376) stabilizes and activates FoxM1 (4-7). Forkhead box M1 is expressed in all embryonic tissues but is restricted to proliferating tissues in adults (8). Recent studies have shown that FoxM1 expression is negatively regulated by p53 (9,10). Upregulation of FoxM1 is associated with many human cancers, including prostate, breast, lung, ovary, colon, pancreas, stomach, bladder, liver, and kidney, and may be associated with p53 mutations in some tumors (10,11). As a result, FoxM1 inhibitors have become a topic of interest for potential cancer therapy (12).

Research area

All research areas>Transcription Regulators>FOX
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize FOXM1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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