Rabbit Polyclonal FZD6 antibody (A10503)

$99.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal FZD6 antibody (A10503)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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FZ6 antibody; FZ-6 antibody; HFZ6 antibody; NDNC10 antibody;
Frizzled 6 seven transmembrane spanning receptor antibody|Frizzled drosophila homolog of 6 antibody|Frizzled family receptor 6 antibody|Frizzled homolog 6 (Drosophila) antibody|Frizzled homolog 6 antibody|Frizzled-6 antibody|Frizzled6 antibody|Fz 6 antibody|Fz-6 antibody|Fz6 antibody|FZD 6 antibody|Fzd6 antibody|FZD6_HUMAN antibody|Hfz 6 antibody|hFz6 antibody|NDNC10 antibody|Anti-Frizzled 6 antibody [EPR7279] (ab128916)

SCBT cat No: sc-393791|sc-393113|sc-32148|sc-32152|

Name

Rabbit Polyclonal FZD6 antibody

Catalogue No.

A10503

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human FZD6

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

79kDa

Formulation

FZD6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FZ6 antibody; FZ-6 antibody; HFZ6 antibody; NDNC10 antibody;

Protein names

FZ6; FZ-6; HFZ6; NDNC10;

Protein function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).

Protein tissue specificity

Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.

Protein sequence and domain

Belongs to the G-protein coupled receptor Fz/Smo family.; Contains 1 FZ (frizzled) domain. Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.; The FZ domain is involved in binding with Wnt ligands.

Protein post-translational modifications

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

Protein cellular localization

Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cell surface . Apical cell membrane; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Note=Colocalizes with FZD3 at the apical face of cells (By similarity).

Background

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

Research area

<a href="http://antibodyplus.com/research-areas/">All research areas</a>><a href="http://antibodyplus.com/Membrane-Receptors/">Membrane Receptors</a>><a href="http://antibodyplus.com/product-tag/frizzled-6/">frizzled-6</a><br><a href="http://antibodyplus.com/product-tag/Membrane-Receptors/"&gt; (View all antibody categories related to Membrane Receptors)</a>

Note

AntibodyPlus can customize FZD6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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