Rabbit polyclonal FZD9 antibody (A8311)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal FZD9 antibody (A8311)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal FZD9 antibody.

Alternative names:

Check alternative names for the antibody

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FZD3 antibody, CD349 antibody
CD 349 antibody|CD 349 antigen antibody|CD349 antibody|Frizzled Drosophila homolog of 3 antibody|Frizzled homolog 9 (Drosophila) antibody|Frizzled homolog 9 antibody|Frizzled-9 antibody|Fz 9 antibody|Fz-9 antibody|FZD 3 antibody|Fzd 9 antibody|FZD3 antibody|FZD3-PEN antibody|FZD9 antibody|FZD9_HUMAN antibody|FzE6 antibody|hFz9 antibody|mfz9 antibody|Xfz9 antibody|Anti-Frizzled 9 antibody (ab61430)

SCBT cat No: sc-33509|

Name

Rabbit polyclonal FZD9 antibody

Catalogue No.

A8311

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human FZD9

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 64kDa/Observed: Refer to figures

Formulation

FZD9 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

FZD9 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FZD3 antibody, CD349 antibody

Database links

Human UniProt/Swiss-Prot:O00144

Protein names

FZD3, CD349

Protein function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Protein tissue specificity

Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney.

Protein sequence and domain

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.; The FZ domain is involved in binding with Wnt ligands.Belongs to the G-protein coupled receptor Fz/Smo family.; Contains 1 FZ (frizzled) domain.

Protein post-translational modifications

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

Protein cellular localization

Cell membrane ; Multi-pass membrane protein .

Background

Members of the ‘frizzled’ gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.

Research area

All research areas>Membrane Receptors>frizzled
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize FZD9 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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