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Rabbit polyclonal G6PD antibody (A1537)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal G6PD antibody.
Check alternative names for the antibodyExpand
G6PD antibody, G6PD1 antibody
G6PD antibody|G6PD_HUMAN antibody|G6PD1 antibody|G6pdx antibody|Glucose 6 phosphate 1 dehydrogenase antibody|Glucose 6 phosphate dehydrogenase antibody|Glucose 6 phosphate dehydrogenase, G6PD antibody|Glucose-6-phosphate 1-dehydrogenase antibody|MET19 antibody|POS10 antibody|Zwf1p antibody|Anti-Glucose 6 Phosphate Dehydrogenase antibody (ab993)
SCBT cat No: sc-46968|sc-373886|sc-373887|sc-67165|sc-46971|
Rabbit polyclonal G6PD antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human G6PD
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 59kDa/Observed: Refer to Figures
G6PD antibody was tube-contained.
G6PD antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
G6PD antibody, G6PD1 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.
|Protein tissue specificity|| |
Isoform Long is found in lymphoblasts, granulocytes and sperm.
|Protein sequence and domain|| |
Belongs to the glucose-6-phosphate dehydrogenase family.
|Protein post-translational modifications|| |
Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity.
Glucose-6-phosphate dehydrogenase (G6PD) catalyses the first and rate-limiting step of the pentose phosphate pathway (1). The NADPH generated from this reaction is essential to protect cells from oxidative stress (1). Recent studies have shown that p53 interacts with G6PD and inhibits its activity, therefore suppressing glucose consumption through the pentose phosphate pathway (2). In cancer cells with p53 mutations, the increased glucose consumption is directed towards increased biosynthesis, which is critical for cancer cell proliferation (2).
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|Product type|| |
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