Rabbit polyclonal GABRB2 antibody (A1876)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GABRB2 antibody (A1876)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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GABA antibody|GABA(A) receptor beta 2 antibody|GABA(A) receptor subunit beta-2 antibody|GABA-A receptor, beta-2 polypeptide antibody|GABRB2 antibody|Gamma aminobutyric acid (GABA) A receptor, beta 2 antibody|Gamma aminobutyric acid A receptor beta 2 antibody|Gamma-aminobutyric acid receptor subunit beta-2 antibody|Gamma-aminobutyric-acid receptor subunit beta-2 antibody|GBRB2_HUMAN antibody|Anti-GABA A Receptor beta 2 antibody (ab186875)

SCBT cat No: sc-7362|sc-31429|sc-133601|sc-7363|sc-31427|sc-31428|

Name

Rabbit polyclonal GABRB2 antibody

Catalogue No.

A1876

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GABRB2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 59kDa/Observed: Refer to Figures

Formulation

GABRB2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GABRB2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:P47870

Protein function

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.

Protein tissue specificity

Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.

Protein sequence and domain

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily.

Protein cellular localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Background

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion.

Research area

All research areas>Channel Proteins>GABA Receptor
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize GABRB2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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