Rabbit polyclonal GALE antibody (A6595)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GALE antibody (A6595)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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SDR1E1 antibody
FLJ95174 antibody|FLJ97302 antibody|Galactose 4 epimerase UDP antibody|Galactowaldenase antibody|galE antibody|GALE_HUMAN antibody|OTTHUMP00000002991 antibody|OTTHUMP00000002994 antibody|OTTHUMP00000037931 antibody|OTTHUMP00000044857 antibody|SDR1E1 antibody|short chain dehydrogenase/reductase family 1E member 1 antibody|UDP galactose 4 epimerase antibody|UDP galactose 4′ epimerase antibody|UDP glucose 4 epimerase antibody|UDP-galactose 4-epimerase antibody|UDP-glucose 4-epimerase antibody|Anti-GALE antibody [EPR11088(B)] (ab155997)

SCBT cat No: sc-390407|sc-390460|sc-160059|

Name

Rabbit polyclonal GALE antibody

Catalogue No.

A6595

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GALE

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 38kDa/Observed: Refer to figures

Formulation

GALE antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GALE antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SDR1E1 antibody

Database links

Human UniProt/Swiss-Prot:Q14376

Protein names

SDR1E1

Protein function

Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.

Protein sequence and domain

Belongs to the NAD(P)-dependent epimerase/dehydratase family.

Background

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild (‘peripheral’ form) to severe (‘generalized’ form). Multiple alternatively spliced transcripts encoding the same protein have been identified.

Note

AntibodyPlus can customize GALE antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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