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Rabbit polyclonal GALE antibody (A6595)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
FLJ95174 antibody|FLJ97302 antibody|Galactose 4 epimerase UDP antibody|Galactowaldenase antibody|galE antibody|GALE_HUMAN antibody|OTTHUMP00000002991 antibody|OTTHUMP00000002994 antibody|OTTHUMP00000037931 antibody|OTTHUMP00000044857 antibody|SDR1E1 antibody|short chain dehydrogenase/reductase family 1E member 1 antibody|UDP galactose 4 epimerase antibody|UDP galactose 4′ epimerase antibody|UDP glucose 4 epimerase antibody|UDP-galactose 4-epimerase antibody|UDP-glucose 4-epimerase antibody|Anti-GALE antibody [EPR11088(B)] (ab155997)
SCBT cat No: sc-390407|sc-390460|sc-160059|
Rabbit polyclonal GALE antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human GALE
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 38kDa/Observed: Refer to figures
GALE antibody was tube-contained.
GALE antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
|Protein sequence and domain|| |
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild (‘peripheral’ form) to severe (‘generalized’ form). Multiple alternatively spliced transcripts encoding the same protein have been identified.
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|Product type|| |
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