Rabbit polyclonal GAS6 antibody (A8545)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GAS6 antibody (A8545)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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AXSF antibody, AXLLG antibody
AXL receptor tyrosine kinase ligand antibody|AXL stimulatory factor antibody|AXLLG antibody|AXS F antibody|AXSF antibody|DKFZp666G247 antibody|FLJ34709 antibody|Gas 6 antibody|GAS-6 antibody|Gas6 antibody|GAS6_HUMAN antibody|Growth arrest specific 6 antibody|Growth arrest-specific protein 6 antibody|Growth-arrest-specific protein 6 antibody|Growth-arrest-specific protein 6 precursor antibody|Anti-GAS 6 antibody (ab136249)

SCBT cat No: sc-376087|sc-1935|sc-16660|sc-22759|sc-1936|

Name

Rabbit polyclonal GAS6 antibody

Catalogue No.

A8545

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human GAS6

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 80kDa/Observed: Refer to figures

Formulation

GAS6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GAS6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

AXSF antibody, AXLLG antibody

Database links

Human UniProt/Swiss-Prot:Q14393

Protein names

AXSF, AXLLG

Protein function

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.; (Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry . Plays a role in Dengue cell entry by apoptotic mimicry . Plays a role in Vaccinia virus cell entry by apoptotic mimicry . Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry .

Protein tissue specificity

Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen.

Protein sequence and domain

Contains 4 EGF-like domains.; Contains 1 Gla (gamma-carboxy-glutamate) domain.; Contains 2 laminin G-like domains.

Protein post-translational modifications

Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.; Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

Protein cellular localization

Secreted .

Background

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia.

Research area

All research areas>Tumor Suppressor/Apoptosis>Gas
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize GAS6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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Antibody customer reviews & validation data - 206

Validation data ID: 206

Submission date: 2017-06-30

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Result figure

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Figure is labelled with sample names very well

Product name

Rabbit polyclonal GAS6 antibody (A8545)

Product catalog No.

A8545

Product type

Primary antibody

Supplier

ABclonal

Application type

Western Blot(WB)

Antibody specificity rating

Good

Antibody overall rating

Good

Your comments

This lot of Gas6 antibody works well on my WB, hopefully, you have enough antibody for our research from the same lot.

Detailed protocol

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