Rabbit polyclonal GCKR antibody (A5678)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GCKR antibody (A5678)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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GKRP antibody, FGQTL5 antibody
FGQTL5 antibody|GCK antibody|GCKR antibody|GCKR_HUMAN antibody|GKRP antibody|GLRE antibody|glucokinase (hexokinase 4) regulator antibody|Glucokinase antibody|Glucokinase regulator antibody|Glucokinase regulatory protein antibody|Hexokinase 4 regulator antibody|Hexokinase type IV antibody|Hexokinase-4 antibody|Hexokinase-D antibody|HK IV antibody|HK4 antibody|OTTHUMP00000158533 antibody|Anti-GCKR antibody (ab65224)

SCBT cat No: sc-166841|sc-74544|sc-11416|sc-6340|

Name

Rabbit polyclonal GCKR antibody

Catalogue No.

A5678

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GCKR

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 69kDa/Observed: Refer to figures

Formulation

GCKR antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GCKR antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GKRP antibody, FGQTL5 antibody

Database links

Human UniProt/Swiss-Prot:Q14397

Protein names

GKRP, FGQTL5

Protein function

Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.

Protein tissue specificity

Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.

Protein sequence and domain

Fructose 1-phosphate and fructose 6-phosphate compete for the same binding site.Belongs to the GCKR family.; Contains 2 SIS domains.

Protein cellular localization

Cytoplasm . Nucleus . Note: Under low glucose concentrations, GKRP associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.

Background

This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).

Research area

All research areas>Signaling Intermediates>GCKR
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize GCKR antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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