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Rabbit polyclonal GCKR antibody (A5678)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal GCKR antibody.
Check alternative names for the antibodyExpand
GKRP antibody, FGQTL5 antibody
FGQTL5 antibody|GCK antibody|GCKR antibody|GCKR_HUMAN antibody|GKRP antibody|GLRE antibody|glucokinase (hexokinase 4) regulator antibody|Glucokinase antibody|Glucokinase regulator antibody|Glucokinase regulatory protein antibody|Hexokinase 4 regulator antibody|Hexokinase type IV antibody|Hexokinase-4 antibody|Hexokinase-D antibody|HK IV antibody|HK4 antibody|OTTHUMP00000158533 antibody|Anti-GCKR antibody (ab65224)
SCBT cat No: sc-166841|sc-74544|sc-11416|sc-6340|
Rabbit polyclonal GCKR antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human GCKR
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 69kDa/Observed: Refer to figures
GCKR antibody was tube-contained.
GCKR antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
GKRP antibody, FGQTL5 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
|Protein tissue specificity|| |
Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.
|Protein sequence and domain|| |
Fructose 1-phosphate and fructose 6-phosphate compete for the same binding site.Belongs to the GCKR family.; Contains 2 SIS domains.
|Protein cellular localization|| |
Cytoplasm . Nucleus . Note: Under low glucose concentrations, GKRP associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
AntibodyPlus can customize GCKR antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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