Rabbit polyclonal GDF15 antibody (A0185)

$69.00$259.00

Reactivity: Human,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GDF15 antibody (A0185)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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GDF15 antibody,GDF-15 antibody,MIC-1 antibody,MIC1 antibody,NAG-1 antibody,PDF antibody,PLAB antibody,PTGFB antibody,Growth/differentiation factor 15 antibody,Placental TGF-beta antibody,Placental bone morphogenetic protein antibody,Prostate differentiation factor antibody
GDF 15 antibody|GDF-15 antibody|Gdf15 antibody|GDF15_HUMAN antibody|Growth differentiation factor 15 antibody|Growth/differentiation factor 15 antibody|Macrophage inhibitory cytokine 1 antibody|MIC 1 antibody|Mic-1 antibody|MIC1 antibody|NAG 1 antibody|NAG-1 antibody|NAG1 antibody|NRG 1 antibody|NRG-1 antibody|NRG1 antibody|NSAID (nonsteroidal anti inflammatory drug) activated protein 1 antibody|NSAID antibody|NSAID regulated protein 1 antibody|NSAID-activated gene 1 protein antibody|NSAID-regulated gene 1 protein antibody|PDF antibody|PLAB antibody|Placental bone morphogenetic protein antibody|Placental bone morphogenic protein antibody|Placental TGF beta antibody|Placental TGF-beta antibody|Prostate differentiation factor antibody|PTGF beta antibody|PTGFB antibody|Anti-GDF15 antibody [EPR19939] (ab206414)

SCBT cat No: sc-46248|sc-46249|sc-10607|sc-66904|sc-377195|sc-10603|sc-46250|

Name

Rabbit polyclonal GDF15 antibody

Catalogue No.

A0185

Reactivity

Human, Rat

Immunogen

Recombinant protein of human GDF15

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 34.15kDa/Observed: Refer to Figures

Formulation

GDF15 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GDF15 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GDF15 antibody,GDF-15 antibody,MIC-1 antibody,MIC1 antibody,NAG-1 antibody,PDF antibody,PLAB antibody,PTGFB antibody,Growth/differentiation factor 15 antibody,Placental TGF-beta antibody,Placental bone morphogenetic protein antibody,Prostate differentiation factor antibody

Database links

Human UniProt/Swiss-Prot:Q99988

Protein names

GDF15,GDF-15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB,Growth/differentiation factor 15,Placental TGF-beta,Placental bone morphogenetic protein,Prostate differentiation factor

Protein tissue specificity

Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney.

Protein sequence and domain

Belongs to the TGF-beta family.

Protein cellular localization

Secreted .

Background

Macrophage inhibitory cytokine-1 (Mic-1), also termed GDF15 (1), PTGF-beta (2), PLAB (3), PDF (4), and NAG-1 (5), is a divergent member of the transforming growth factor-beta (TGF-beta) superfamily (6). Like other family members, Mic-1 is synthesized as an inactive precursor that undergoes proteolytic processing involving removal of an N-terminal hydrophobic signal sequence followed by cleavage at a conserved RXXR site generating an active C-terminal domain that is secreted as a dimeric protein. Mic-1 is highly expressed in the placenta and is also dramatically increased by cellular stress, acute injury, inflammation, and cancer. In the brain, Mic-1 is found in the choroid plexus and is secreted into the cerebrospinal fluid (7). It is also a transcriptional target of the p53 tumor suppressor protein and may serve as a biomarker for p53 activity (8,9). During tumor progression, Mic-1 has various effects on apoptosis, differentiation, angiogenisis, and metastasis, and may also contribute to weight loss during cancer (10,11).

Research area

All research areas>Growth Factors and Hormones>GDF
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize GDF15 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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