Rabbit polyclonal GEMIN2 antibody (A3082)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GEMIN2 antibody (A3082)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:1000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal GEMIN2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

SIP1 antibody, SIP1-delta antibody
Component of gems 2 antibody|Gem (nuclear organelle) associated protein 2 antibody|Gem associated protein 2 antibody|GEMI2_HUMAN antibody|Gemin-2 antibody|gemin2 antibody|SIP 1 antibody|SIP-1 antibody|SIP1 antibody|SIP1 delta antibody|SIP1-delta antibody|SMN interacting protein 1 antibody|SMN interacting protein 1 delta antibody|SMN-interacting protein 1 antibody|Survival interacting protein 1 antibody|Survival of motor neuron protein interacting protein 1 antibody|Survival of motor neuron protein-interacting protein 1 antibody|Anti-Gemin 2 antibody [2E17] (ab6084)

SCBT cat No: sc-33703|sc-32806|sc-135918|sc-166187|sc-7801|sc-166160|sc-166162|sc-166161|sc-50404|

Name

Rabbit polyclonal GEMIN2 antibody

Catalogue No.

A3082

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human GEMIN2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:1000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 32kDa/Observed: Refer to Figures

Formulation

GEMIN2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GEMIN2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SIP1 antibody, SIP1-delta antibody

Database links

Human UniProt/Swiss-Prot:O14893

Protein names

SIP1, SIP1-delta

Protein function

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

Protein sequence and domain

Belongs to the gemin-2 family.

Protein cellular localization

Nucleus, gem. Cytoplasm. Note: Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.

Background

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.

Research area

All research areas>Neurobiology>Gemin
(View all antibody categories related to Neurobiology)

Note

AntibodyPlus can customize GEMIN2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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