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Rabbit polyclonal GEMIN2 antibody (A3082)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:1000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal GEMIN2 antibody.
Check alternative names for the antibodyExpand
SIP1 antibody, SIP1-delta antibody
Component of gems 2 antibody|Gem (nuclear organelle) associated protein 2 antibody|Gem associated protein 2 antibody|GEMI2_HUMAN antibody|Gemin-2 antibody|gemin2 antibody|SIP 1 antibody|SIP-1 antibody|SIP1 antibody|SIP1 delta antibody|SIP1-delta antibody|SMN interacting protein 1 antibody|SMN interacting protein 1 delta antibody|SMN-interacting protein 1 antibody|Survival interacting protein 1 antibody|Survival of motor neuron protein interacting protein 1 antibody|Survival of motor neuron protein-interacting protein 1 antibody|Anti-Gemin 2 antibody [2E17] (ab6084)
SCBT cat No: sc-33703|sc-32806|sc-135918|sc-166187|sc-7801|sc-166160|sc-166162|sc-166161|sc-50404|
Rabbit polyclonal GEMIN2 antibody
|Catalogue No.|| |
Human, Mouse, Rat
A synthetic peptide of human GEMIN2
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:1000
|Molecular weight|| |
Predicted: 32kDa/Observed: Refer to Figures
GEMIN2 antibody was tube-contained.
GEMIN2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
SIP1 antibody, SIP1-delta antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
|Protein sequence and domain|| |
Belongs to the gemin-2 family.
|Protein cellular localization|| |
Nucleus, gem. Cytoplasm. Note: Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
AntibodyPlus can customize GEMIN2 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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