Rabbit polyclonal GGA2 antibody (A1186)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GGA2 antibody (A1186)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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GGA2 antibody,FLJ20966 antibody,KIAA1080 antibody,VEAR antibody
1200007E24Rik antibody|gamma ear-containing antibody|GGA 2 antibody|Gga2 antibody|GGA2_HUMAN antibody|Golgi associated gamma adaptin ear containing ARF binding protein 2 antibody|Golgi localized gamma ear containing ARF binding protein 2 antibody|Golgi-localized antibody|KIAA1080 antibody|Vear antibody|VHS domain and ear domain containing protein antibody|VHS domain and ear domain of gamma adaptin antibody|VHS domain and ear domain of gamma-adaptin antibody|Anti-GGA2 antibody (ab153928)

SCBT cat No: sc-135922|sc-133147|sc-30103|

Name

Rabbit polyclonal GGA2 antibody

Catalogue No.

A1186

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GGA2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 67kDa/Observed: Refer to Figures

Formulation

GGA2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GGA2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GGA2 antibody,FLJ20966 antibody,KIAA1080 antibody,VEAR antibody

Database links

Human UniProt/Swiss-Prot:Q9UJY4

Protein names

GGA2,FLJ20966,KIAA1080,VEAR

Protein function

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

Protein tissue specificity

Ubiquitously expressed.

Protein sequence and domain

The VHS domain functions as a recognition module for sorting signals composed of an acidic cluster followed by two leucines (AC-LL motif).; The GAT domain is responsible for interaction with ARF-GTP, UBC and RABEP1. Required for recruitment to the TGN it prevents ARF-GTP hydrolysis.; The unstructured hinge region contains clathrin-binding but no autoinhibitory (AC-LL) motifs.; The GAE domain binds accessory proteins regulating GGAs function.Belongs to the GGA protein family.; Contains 1 GAE domain.; Contains 1 GAT domain.; Contains 1 VHS domain.

Protein post-translational modifications

Ubiquitinated.

Protein cellular localization

Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein .

Background

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. [provided by RefSeq, Jul 2008]

Note

AntibodyPlus can customize GGA2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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