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Rabbit polyclonal GLRX2 antibody (A6603)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal GLRX2 antibody.
Check alternative names for the antibodyExpand
GRX2 antibody, CGI-133 antibody
bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2) antibody|bA101E13.1 antibody|CGI133 antibody|Glrx2 antibody|GLRX2_HUMAN antibody|Glutaredoxin-2 antibody|Glutaredoxin-2, mitochondrial antibody|GRX2 antibody|mitochondrial antibody|Anti-Glutaredoxin 2 antibody – C-terminal (ab85267)
SCBT cat No:
Rabbit polyclonal GLRX2 antibody
|Catalogue No.|| |
Recombinant protein of human GLRX2
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 18kDa/Observed: Refer to figures
GLRX2 antibody was tube-contained.
GLRX2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
GRX2 antibody, CGI-133 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
|Protein tissue specificity|| |
Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes.
|Protein sequence and domain|| |
Belongs to the glutaredoxin family.; Contains 1 glutaredoxin domain.
|Protein cellular localization|| |
Isoform 1: Mitochondrion.; Isoform 2: Nucleus.
The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression.
AntibodyPlus can customize GLRX2 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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