Rabbit polyclonal GLRX2 antibody (A6603)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GLRX2 antibody (A6603)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal GLRX2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

GRX2 antibody, CGI-133 antibody
bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2) antibody|bA101E13.1 antibody|CGI133 antibody|Glrx2 antibody|GLRX2_HUMAN antibody|Glutaredoxin-2 antibody|Glutaredoxin-2, mitochondrial antibody|GRX2 antibody|mitochondrial antibody|Anti-Glutaredoxin 2 antibody – C-terminal (ab85267)

SCBT cat No:

Name

Rabbit polyclonal GLRX2 antibody

Catalogue No.

A6603

Reactivity

Human

Immunogen

Recombinant protein of human GLRX2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 18kDa/Observed: Refer to figures

Formulation

GLRX2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GLRX2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GRX2 antibody, CGI-133 antibody

Database links

Human UniProt/Swiss-Prot:Q9NS18

Protein names

GRX2, CGI-133

Protein function

Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

Protein tissue specificity

Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes.

Protein sequence and domain

Belongs to the glutaredoxin family.; Contains 1 glutaredoxin domain.

Protein cellular localization

Isoform 1: Mitochondrion.; Isoform 2: Nucleus.

Background

The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression.

Note

AntibodyPlus can customize GLRX2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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