Rabbit polyclonal GLRX3 antibody (A5892)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GLRX3 antibody (A5892)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal GLRX3 antibody.

Alternative names:

Check alternative names for the antibody

Expand

GRX3 antibody, GRX4 antibody, GLRX4 antibody, PICOT antibody, TXNL2 antibody, TXNL3 antibody
glrx3 antibody|GLRX3_HUMAN antibody|GLRX4 antibody|Glutaredoxin 3 antibody|Glutaredoxin 4 antibody|Glutaredoxin-3 antibody|GRX3 antibody|GRX4 antibody|PICOT antibody|PKC interacting cousin of thioredoxin antibody|PKC theta interacting protein antibody|PKC-interacting cousin of thioredoxin antibody|PKC-theta-interacting protein antibody|PKCq interacting protein antibody|PKCq-interacting protein antibody|Thioredoxin like protein 2 antibody|Thioredoxin-like protein 2 antibody|TXNL3 antibody|Anti-TXNL2 antibody – N-terminal (ab211298)

SCBT cat No: sc-390068|sc-100601|sc-69309|

Name

Rabbit polyclonal GLRX3 antibody

Catalogue No.

A5892

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GLRX3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 37kDa/Observed: Refer to Figures

Formulation

GLRX3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GLRX3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GRX3 antibody, GRX4 antibody, GLRX4 antibody, PICOT antibody, TXNL2 antibody, TXNL3 antibody

Database links

Human UniProt/Swiss-Prot:O76003

Protein names

GRX3, GRX4, GLRX4, PICOT, TXNL2, TXNL3

Protein function

Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.

Protein tissue specificity

Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.

Protein sequence and domain

The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity.Contains 2 glutaredoxin domains.; Contains 1 thioredoxin domain.

Protein cellular localization

Cytoplasm, cell cortex . Cytoplasm, myofibril, sarcomere, Z line . Note: Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity).

Background

This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene.

Note

AntibodyPlus can customize GLRX3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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