Rabbit polyclonal GLUD1 antibody (A7631)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GLUD1 antibody (A7631)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal GLUD1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

GDH antibody, GDH1 antibody, GLUD antibody
GDH 1 antibody|GDH 2 antibody|GLUD antibody|GLUD1 antibody|GLUD2 antibody|GLUDP1 antibody|Glutamate dehydrogenase 1, mitochondrial antibody|Glutamate dehydrogenase 2, mitochondrial antibody|Anti-GLUD1 + GLUD2 antibody (ab99470)

SCBT cat No: sc-293459|

Name

Rabbit polyclonal GLUD1 antibody

Catalogue No.

A7631

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GLUD1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:100 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 61kDa/Observed: Refer to figures

Formulation

GLUD1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GLUD1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GDH antibody, GDH1 antibody, GLUD antibody

Database links

Human UniProt/Swiss-Prot:P00367

Protein names

GDH, GDH1, GLUD

Protein function

Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).

Protein sequence and domain

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Protein post-translational modifications

ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity (By similarity). Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.

Protein cellular localization

Mitochondrion matrix.

Background

This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.

Note

AntibodyPlus can customize GLUD1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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