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Rabbit polyclonal GMNN antibody (A5316)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal GMNN antibody.
Check alternative names for the antibodyExpand
DNA replication inhibitor antibody|Gem antibody|GEMI_HUMAN antibody|Geminin antibody|Geminin DNA replication inhibitor antibody|GMNN antibody|OTTHUMP00000039393 antibody|RP3 369A17.3 antibody|Anti-Geminin antibody (ab12147)
SCBT cat No: sc-74496|sc-8448|sc-74456|sc-13015|sc-374187|sc-8450|sc-8449|
Rabbit polyclonal GMNN antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human GMNN
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 23kDa/Observed: Refer to Figures
GMNN antibody was tube-contained.
GMNN antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.; Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.
|Protein sequence and domain|| |
Belongs to the geminin family.
|Protein post-translational modifications|| |
Phosphorylated during mitosis. Phosphorylation at Ser-184 by CK2 results in enhanced binding to Hox proteins and more potent inhibitory effect on Hox transcriptional activity.
|Protein cellular localization|| |
Cytoplasm. Nucleus. Note: Mainly cytoplasmic but can be relocalized to the nucleus.
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
AntibodyPlus can customize GMNN antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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