Rabbit polyclonal GMNN antibody (A5316)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GMNN antibody (A5316)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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Gem antibody
DNA replication inhibitor antibody|Gem antibody|GEMI_HUMAN antibody|Geminin antibody|Geminin DNA replication inhibitor antibody|GMNN antibody|OTTHUMP00000039393 antibody|RP3 369A17.3 antibody|Anti-Geminin antibody (ab12147)

SCBT cat No: sc-74496|sc-8448|sc-74456|sc-13015|sc-374187|sc-8450|sc-8449|

Name

Rabbit polyclonal GMNN antibody

Catalogue No.

A5316

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GMNN

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 23kDa/Observed: Refer to Figures

Formulation

GMNN antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GMNN antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

Gem antibody

Database links

Human UniProt/Swiss-Prot:O75496

Protein names

Gem

Protein function

Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.; Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.

Protein sequence and domain

Belongs to the geminin family.

Protein post-translational modifications

Phosphorylated during mitosis. Phosphorylation at Ser-184 by CK2 results in enhanced binding to Hox proteins and more potent inhibitory effect on Hox transcriptional activity.

Protein cellular localization

Cytoplasm. Nucleus. Note: Mainly cytoplasmic but can be relocalized to the nucleus.

Background

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.

Note

AntibodyPlus can customize GMNN antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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