Rabbit polyclonal GNA11 antibody (A2731)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GNA11 antibody (A2731)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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GNA-11 antibody
G alpha-11 antibody|G-protein subunit alpha-11 antibody|GA11 antibody|GNA11 antibody|GNA11_HUMAN antibody|guanine nucleotide binding protein (G protein), alpha 11 (Gq class) antibody|Guanine nucleotide-binding protein G(y) subunit alpha antibody|Guanine nucleotide-binding protein subunit alpha-11 antibody|guanine nucleotide-binding protein, alpha 11 antibody|guanine nucleotide-binding protein, Gq class, GNA11 antibody|Anti-GNA11 antibody (ab153951)

SCBT cat No: sc-394|sc-390382|sc-26792|sc-28588|sc-515445|

Name

Rabbit polyclonal GNA11 antibody

Catalogue No.

A2731

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GNA11

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 42kDa/Observed: Refer to Figures

Formulation

GNA11 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GNA11 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GNA-11 antibody

Database links

Human UniProt/Swiss-Prot:P29992

Protein names

GNA-11

Protein function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

Protein tissue specificity

Expressed in testis.

Protein sequence and domain

Belongs to the G-alpha family. G(q) subfamily.

Protein post-translational modifications

(Microbial infection) Deamidated at Gln-209 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.

Protein cellular localization

Cell membrane ; Lipid-anchor . Cytoplasm . Note: In testicular cells, expressed exclusively in the cytoplasm.

Background

Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of alpha, beta and gamma subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Galpha subunits have been classified into four families, Galpha(s), Galpha(i/o), Galpha(q) and Galpha(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Galpha(q)/Galpha(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Galpha with receptors and abolishes ligand-induced IP3 formation (3).

Research area

All research areas>GDP/GTP Binding Proteins>Heterotrimeric G Protein
(View all antibody categories related to GDP/GTP Binding Proteins)

Note

AntibodyPlus can customize GNA11 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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