Rabbit polyclonal GNAI3 antibody (A1922)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GNAI3 antibody (A1922)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:1000 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal GNAI3 antibody.

Alternative names:

Check alternative names for the antibody

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87U6 antibody, ARCND1 antibody
87U6 antibody|FLJ26559 antibody|G protein alpha inhibiting 3 antibody|G(i) alpha 3 antibody|G(i) alpha-3 antibody|GNAI3 antibody|GNAI3_HUMAN antibody|Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 antibody|Guanine nucleotide binding protein G(k) alpha subunit antibody|Guanine nucleotide-binding protein G(k) subunit alpha antibody|OTTHUMP00000013368 antibody|Anti-GNAI3 antibody [EPR11900] (ab176339)

SCBT cat No: sc-391|sc-13533|

Name

Rabbit polyclonal GNAI3 antibody

Catalogue No.

A1922

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human GNAI3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:1000 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 41kDa/Observed: Refer to figures

Formulation

GNAI3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GNAI3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

87U6 antibody, ARCND1 antibody

Database links

Human UniProt/Swiss-Prot:P08754

Protein names

87U6, ARCND1

Protein function

Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins . Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels . Stimulates the activity of receptor-regulated K(+) channels . The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division .

Protein sequence and domain

Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Protein post-translational modifications

(Microbial infection) Deamidated at Gln-204 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.

Protein cellular localization

Cytoplasm . Cell membrane . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Membrane ; Lipid-anchor . Note: Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.

Background

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway.

Research area

All research areas>GDP/GTP Binding Proteins>Heterotrimeric G Protein
(View all antibody categories related to GDP/GTP Binding Proteins)

Note

AntibodyPlus can customize GNAI3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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