Rabbit polyclonal GNAS antibody (A5546)


Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GNAS antibody (A5546)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal GNAS antibody.

Alternative names:

Check alternative names for the antibody


AHO antibody, GSA antibody, GSP antibody, POH antibody, GPSA antibody, NESP antibody, GNAS1 antibody, PHP1A antibody, PHP1B antibody, PHP1C antibody, C20orf45 antibody
Adenylate cyclase stimulating G alpha protein antibody|AHO antibody|Alternative gene product encoded by XL exon antibody|C20orf45 antibody|dJ309F20.1.1 antibody|dJ806M20.3.3 antibody|Extra large alphas protein antibody|GNAS antibody|GNAS complex locus antibody|GNAS1 antibody|GPSA antibody|Gs alpha subunit antibody|GSA antibody|GSP antibody|Guanine nucleotide binding protein (G protein) alpha stimulating activity polypeptide 1 antibody|Guanine nucleotide binding protein alpha stimulating activity polypeptide 1 antibody|Guanine nucleotide binding protein G(s) subunit alpha isoforms short antibody|Guanine nucleotide binding protein G(s) subunit alpha isoforms XLas antibody|Guanine nucleotide regulatory protein antibody|MGC33735 antibody|NESP antibody|NESP55 antibody|Neuroendocrine secretory protein antibody|PHP1A antibody|PHP1B antibody|PHP1C antibody|POH antibody|Protein ALEX antibody|Protein GNAS antibody|Protein NESP55 antibody|SCG6 antibody|Secretogranin VI antibody|XLalphas antibody|XLas antibody|Anti-G protein alpha S antibody (ab83735)

SCBT cat No: sc-377435|sc-383|sc-55546|sc-365855|sc-28585|sc-135914|sc-26766|sc-46975|sc-46976|sc-823|


Rabbit polyclonal GNAS antibody

Catalogue No.



Human, Mouse, Rat


Recombinant protein of human GNAS





Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200







Molecular weight

Predicted: 67kDa/Observed: Refer to Figures


GNAS antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


GNAS antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

AHO antibody, GSA antibody, GSP antibody, POH antibody, GPSA antibody, NESP antibody, GNAS1 antibody, PHP1A antibody, PHP1B antibody, PHP1C antibody, C20orf45 antibody

Database links

Human UniProt/Swiss-Prot:P63092

Protein names


Protein function

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) . Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP . GNAS functions downstream of several GPCRs, including beta-adrenergic receptors . Stimulates the Ras signaling pathway via RAPGEF2 .

Protein sequence and domain

Belongs to the G-alpha family. G(s) subfamily.

Protein cellular localization

Cell membrane ; Lipid-anchor .


This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5′ exons. Some transcripts contain a differentially methylated region (DMR) at their 5′ exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein – Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.


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Product type

Primary antibody


ABclonal Inc.


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