Rabbit polyclonal GNE antibody (A8570)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GNE antibody (A8570)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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NM antibody, DMRV antibody, IBM2 antibody, Uae1 antibody, GLCNE antibody
2310066H07Rik antibody|Bifunctional UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase antibody|DMRV antibody|GLCNE_HUMAN antibody|Glucosamine (UDP N acetyl) 2 epimerase/N acetylmannosamine kinase antibody|GNE antibody|IBM2 antibody|ManAc kinase antibody|N acylmannosamine kinase antibody|N-acetylmannosamine kinase antibody|NM antibody|RP23-209M8.6 antibody|Uae1 antibody|UDP GlcNAc 2 epimerase antibody|UDP GlcNAc 2 epimerase/ManAc kinase antibody|UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase antibody|UDP-GlcNAc-2-epimerase antibody|UDP-GlcNAc-2-epimerase/ManAc kinase antibody|Uridine diphosphate N acetylglucosamine 2 epimerase antibody|Uridine diphosphate-N-acetylglucosamine-2-epimerase antibody|Anti-GLCNE antibody [EPR15059] – C-terminal (ab189927)

SCBT cat No: sc-374512|sc-271481|sc-376057|sc-49951|

Name

Rabbit polyclonal GNE antibody

Catalogue No.

A8570

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GNE

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 79kDa/Observed: Refer to figures

Formulation

GNE antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GNE antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

NM antibody, DMRV antibody, IBM2 antibody, Uae1 antibody, GLCNE antibody

Database links

Human UniProt/Swiss-Prot:Q9Y223

Protein names

NM, DMRV, IBM2, Uae1, GLCNE

Protein function

Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.

Protein tissue specificity

Highest expression in liver and placenta. Also found in heart, brain, lung, kidney, skeletal muscle and pancreas. Isoform 1 is expressed in heart, brain, kidney, liver, placenta, lung, spleen, pancreas, skeletal muscle and colon. Isoform 2 is expressed mainly in placenta, but also in brain, kidney, liver, lung, pancreas and colon. Isoform 3 is expressed at low level in kidney, liver, placenta and colon.

Protein sequence and domain

In the N-terminal section; belongs to the UDP-N-acetylglucosamine 2-epimerase family.; In the C-terminal section; belongs to the ROK (NagC/XylR) family.

Protein post-translational modifications

Phosphorylated by PKC.

Protein cellular localization

Cytoplasm .

Background

The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.

Research area

All research areas>Kinases and Phosphatases>GLCNE
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize GNE antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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