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Rabbit polyclonal GPS1 antibody (A6917)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal GPS1 antibody.
Check alternative names for the antibodyExpand
CSN1 antibody, COPS1 antibody
COP9 signalosome complex subunit 1 antibody|COP9 signalosome subunit 1 antibody|COPS1 antibody|CSN 1 antibody|CSN1_HUMAN antibody|FUS6/COP11, Arabidopsis, homolog of antibody|G protein pathway suppressor 1 antibody|GPS-1 antibody|Gps1 antibody|JAB1-containing signalosome subunit 1 antibody|Protein GPS1 antibody|Protein MFH antibody|SGN1 antibody|Signalosome subunit 1 antibody|Anti-CSN1 antibody [EP15642-22] (ab194359)
SCBT cat No: sc-365617|sc-514086|sc-377134|sc-292637|sc-47854|sc-47856|
Rabbit polyclonal GPS1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human GPS1
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 56kDa/Observed: Refer to figures
GPS1 antibody was tube-contained.
GPS1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
CSN1 antibody, COPS1 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity).; The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression.Belongs to the CSN1 family.; Contains 1 PCI domain.
|Protein cellular localization|| |
Cytoplasm . Nucleus .
This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
AntibodyPlus can customize GPS1 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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