Rabbit polyclonal GRB2 antibody (A5689)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GRB2 antibody (A5689)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:10 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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ASH antibody, Grb3-3 antibody, MST084 antibody, NCKAP2 antibody, MSTP084 antibody, EGFRBP-GRB2 antibody
Abundant SRC homology antibody|Adapter protein GRB2 antibody|ASH antibody|Ash protein antibody|EGFRBP GRB2 antibody|Epidermal growth factor receptor binding protein antibody|Epidermal growth factor receptor binding protein GRB2 antibody|GRB 2 antibody|GRB2 adapter protein antibody|Grb2 antibody|GRB2_HUMAN antibody|Grb3 3 antibody|Growth factor receptor bound protein 2 antibody|Growth factor receptor bound protein 3 antibody|Growth factor receptor-bound protein 2 antibody|HT027 antibody|MST084 antibody|MSTP084 antibody|NCKAP2 antibody|OTTHUMP00000166096 antibody|OTTHUMP00000166097 antibody|OTTHUMP00000166098 antibody|Protein ash antibody|SEM5 antibody|SH2/SH3 adapter GRB2 antibody|Anti-GRB2 antibody [Y237] (ab32037)

SCBT cat No: sc-503|sc-255|sc-365619|sc-8034|sc-17813|sc-137074|sc-28839|sc-13953|sc-137056|

Name

Rabbit polyclonal GRB2 antibody

Catalogue No.

A5689

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GRB2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:10 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 25kDa/Observed: Refer to Figures

Formulation

GRB2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GRB2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ASH antibody, Grb3-3 antibody, MST084 antibody, NCKAP2 antibody, MSTP084 antibody, EGFRBP-GRB2 antibody

Database links

Human UniProt/Swiss-Prot:P62993

Protein names

ASH, Grb3-3, MST084, NCKAP2, MSTP084, EGFRBP-GRB2

Protein function

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.; Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

Protein sequence and domain

The SH3 domains mediate interaction with RALGPS1 and SHB.Belongs to the GRB2/sem-5/DRK family.; Contains 1 SH2 domain.; Contains 2 SH3 domains.

Protein cellular localization

Nucleus . Cytoplasm . Endosome . Golgi apparatus .

Background

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Signaling Intermediates>GRB
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize GRB2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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