Rabbit polyclonal GRIA1 antibody (A1826)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GRIA1 antibody (A1826)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal GRIA1 antibody.

Alternative names:

Check alternative names for the antibody

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GLUH1 antibody, GLUR1 antibody, GLURA antibody, GluA1 antibody, HBGR1 antibody
GLUR 1 antibody| GLUR A antibody|AMPA 1 antibody|AMPA selective glutamate receptor 1 antibody|AMPA-selective glutamate receptor 1 antibody|GluA1 antibody|GLUH1 antibody|GluR K1 antibody|GluR-1 antibody|GluR-A antibody|GluR-K1 antibody|GLUR1 antibody|GLURA antibody|GluRK1 antibody|Glutamate receptor 1 antibody|Glutamate receptor ionotropic AMPA 1 antibody|Glutamate receptor ionotropic antibody|Glutamate receptor, ionotropic, AMPA 1 antibody|Gria1 antibody|GRIA1_HUMAN antibody|HBGR1 antibody|MGC133252 antibody|OTTHUMP00000160643 antibody|OTTHUMP00000165781 antibody|OTTHUMP00000224241 antibody|OTTHUMP00000224242 antibody|OTTHUMP00000224243 antibody|Anti-Glutamate Receptor 1 (AMPA subtype) antibody (ab31232)

SCBT cat No: sc-7609|sc-13152|sc-55509|sc-28799|sc-33612|sc-7610|sc-7611|sc-517202|

Name

Rabbit polyclonal GRIA1 antibody

Catalogue No.

A1826

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GRIA1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 105kDa/Observed: Refer to Figures

Formulation

GRIA1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GRIA1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GLUH1 antibody, GLUR1 antibody, GLURA antibody, GluA1 antibody, HBGR1 antibody

Database links

Human UniProt/Swiss-Prot:P42261

Protein names

GLUH1, GLUR1, GLURA, GluA1, HBGR1

Protein function

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Protein tissue specificity

Widely expressed in brain.

Protein sequence and domain

The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.

Protein post-translational modifications

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell projection, dendrite . Cell projection, dendritic spine . Note: Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.

Background

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Channel Proteins>GluR
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize GRIA1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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