Rabbit polyclonal GRIA4 antibody (A1492)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GRIA4 antibody (A1492)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:1000 – 1:4000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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GLUR4 antibody, GLURD antibody, GluA4 antibody, GLUR4C antibody
AMPA 4 antibody|AMPA selective glutamate receptor 4 antibody|AMPA-selective glutamate receptor 4 antibody|AMPA4 antibody|GluA 4 antibody|GluA4 antibody|GluR 4 antibody|GluR D antibody|GluR-4 antibody|GluR-D antibody|GluR4 antibody|GLUR4C antibody|GLURD antibody|Glutamate receptor 4 antibody|Glutamate receptor ionotrophic AMPA 4 antibody|Glutamate receptor ionotropic antibody|GRIA 4 antibody|Gria4 antibody|GRIA4_HUMAN antibody|Anti-Ionotropic Glutamate receptor 4 antibody (ab77407)

SCBT cat No: sc-7614|sc-271894|sc-31394|

Name

Rabbit polyclonal GRIA4 antibody

Catalogue No.

A1492

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GLUR4

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:1000 – 1:4000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 101kDa/Observed: Refer to Figures

Formulation

GRIA4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GRIA4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GLUR4 antibody, GLURD antibody, GluA4 antibody, GLUR4C antibody

Database links

Human UniProt/Swiss-Prot:P48058

Protein names

GLUR4, GLURD, GluA4, GLUR4C

Protein function

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Protein sequence and domain

The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.

Protein post-translational modifications

Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).; Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression.

Protein cellular localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note: Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression.

Background

AMPA- (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainite-, and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4), which assemble as homo- or hetero-tetramers to mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization, and plasticity (1). AMPARs that lack GluR 2 are permeable to calcium, in contrast to GluR 2-containing AMPARs (2). Post-transcriptional modifications (alternative splicing, nuclear RNA editing) and post-translational modifications (glycosylation, phosphorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs. Research studies have implicated activity changes in AMPARs in a variety of diseases including Alzheimer’s, amyotrophic lateral sclerosis (ALS), stroke, and epilepsy (1).GluR 4 containing AMPA receptors are found in synapses and GluR 4 delivery to synapses and cell surface expression is mediated through phosphorylation of Ser842 by PKA or PKC (3).

Research area

All research areas>Channel Proteins>GluR
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize GRIA4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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