Rabbit polyclonal GRIK2 antibody (A1939)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GRIK2 antibody (A1939)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal GRIK2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

EAA4 antibody, GLR6 antibody, MRT6 antibody, GLUK6 antibody, GLUR6 antibody, GluK2 antibody
bA487F5.1 antibody|EAA4 antibody|Excitatory amino acid receptor 4 antibody|GLR 6 antibody|GLR6 antibody|GluK2 antibody|GLUK6 antibody|GLUR 6 antibody|GluR-6 antibody|GluR6 antibody|Glutamate receptor 6 antibody|Glutamate receptor antibody|glutamate receptor form A antibody|glutamate receptor form B antibody|glutamate receptor form C antibody|glutamate receptor form D antibody|glutamate receptor form E antibody|Glutamate receptor ionotropic kainate 2 antibody|GRIK 2 antibody|GRIK2 antibody|GRIK2 protein antibody|GRIK2_HUMAN antibody|ionotropic kainate 2 antibody|MRT6 antibody|Anti-GRIK2 antibody [EPR6307] (ab124702)

SCBT cat No: sc-7618|

Name

Rabbit polyclonal GRIK2 antibody

Catalogue No.

A1939

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GRIK2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 103kDa/Observed: Refer to Figures

Formulation

GRIK2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GRIK2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EAA4 antibody, GLR6 antibody, MRT6 antibody, GLUK6 antibody, GLUR6 antibody, GluK2 antibody

Database links

Human UniProt/Swiss-Prot:Q13002

Protein names

EAA4, GLR6, MRT6, GLUK6, GLUR6, GluK2

Protein function

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).

Protein tissue specificity

Expression is higher in cerebellum than in cerebral cortex.

Protein sequence and domain

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily.

Protein post-translational modifications

Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1 (By similarity).; Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome (By similarity).; Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation.

Protein cellular localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Background

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.

Research area

All research areas>Channel Proteins>GluR
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize GRIK2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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