Rabbit polyclonal GRK1 antibody (A2966)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GRK1 antibody (A2966)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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RK antibody, RHOK antibody, GPRK1 antibody
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SCBT cat No:

Name

Rabbit polyclonal GRK1 antibody

Catalogue No.

A2966

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human GRK1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 63.5kDa/Observed: Refer to Figures

Formulation

GRK1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GRK1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RK antibody, RHOK antibody, GPRK1 antibody

Database links

Human UniProt/Swiss-Prot:Q15835

Protein names

RK, RHOK, GPRK1

Protein function

Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.

Protein tissue specificity

Retinal-specific. Expressed in rods and cones cells.

Protein sequence and domain

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.; Contains 1 AGC-kinase C-terminal domain.; Contains 1 protein kinase domain.; Contains 1 RGS domain.

Protein post-translational modifications

Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP.; Farnesylation is required for full activity.

Protein cellular localization

Membrane ; Lipid-anchor .

Background

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.

Research area

All research areas>Kinases and Phosphatases>GRK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize GRK1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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