Rabbit polyclonal GRN antibody (A5773)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal GRN antibody (A5773)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal GRN antibody.

Alternative names:

Check alternative names for the antibody

Expand

GEP antibody, GP88 antibody, PEPI antibody, PGRN antibody, CLN11 antibody, PCDGF antibody
Acrogranin antibody|CLN11 antibody|GEP antibody|GP88 antibody|Granulin A antibody|Granulin B antibody|Granulin C antibody|Granulin D antibody|Granulin E antibody|Granulin epithelin antibody|Granulin F antibody|Granulin G antibody|Granulin-7 antibody|Granulins antibody|GRN antibody|GRN_HUMAN antibody|PC cell derived growth factor antibody|PCDGF antibody|PEPI antibody|PGRN antibody|Proepithelin antibody|Progranulin antibody|Anti-Granulin antibody [EPR3781] (ab108608)

SCBT cat No: sc-81151|sc-377036|sc-28928|sc-11348|sc-11342|

Name

Rabbit polyclonal GRN antibody

Catalogue No.

A5773

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human GRN

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 63kDa/Observed: Refer to Figures

Formulation

GRN antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GRN antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GEP antibody, GP88 antibody, PEPI antibody, PGRN antibody, CLN11 antibody, PCDGF antibody

Database links

Human UniProt/Swiss-Prot:P28799

Protein names

GEP, GP88, PEPI, PGRN, CLN11, PCDGF

Protein function

Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.; Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

Protein tissue specificity

In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.

Protein sequence and domain

Belongs to the granulin family.

Protein post-translational modifications

Granulins are disulfide bridged.

Protein cellular localization

Secreted.

Background

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Note

AntibodyPlus can customize GRN antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!