Rabbit polyclonal GSDMB antibody (A7474)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal GSDMB antibody (A7474)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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GSDML antibody, PP4052 antibody, PRO2521 antibody
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SCBT cat No:

Name

Rabbit polyclonal GSDMB antibody

Catalogue No.

A7474

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human GSDMB

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 47kDa/Observed: Refer to figures

Formulation

GSDMB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

GSDMB antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

GSDML antibody, PP4052 antibody, PRO2521 antibody

Database links

Human UniProt/Swiss-Prot:Q8TAX9

Protein names

GSDML, PP4052, PRO2521

Protein function

The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores . The physiological relevance of this observation is unknown (Probable).

Protein tissue specificity

In the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach.

Protein sequence and domain

Intramolecular interactions between N- and C-terminal domains may be important for autoinhibition in the absence of activation signal. The intrinsic pyroptosis-inducing activity is carried by the N-terminal domain.Belongs to the gasdermin family.

Protein cellular localization

Cytoplasm . Cytoplasm, cytosol . Cell membrane . Note: Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells.

Background

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.

Note

AntibodyPlus can customize GSDMB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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