Rabbit polyclonal H2AFZ antibody (A6614)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal H2AFZ antibody (A6614)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal H2AFZ antibody.

Alternative names:

Check alternative names for the antibody

Expand

H2AZ antibody, H2A.z antibody, H2A/z antibody, H2A.Z-1 antibody
H2A histone family member Z antibody|H2A.z antibody|H2A/z antibody|H2afz antibody|H2AZ antibody|H2AZ_HUMAN antibody|Histone H2A.Z antibody|MGC117173 antibody|Anti-Histone H2A.Z antibody (ab4174) ChIP Grade

SCBT cat No: sc-67218|

Name

Rabbit polyclonal H2AFZ antibody

Catalogue No.

A6614

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human H2AFZ

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 13kDa/Observed: Refer to figures

Formulation

H2AFZ antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

H2AFZ antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

H2AZ antibody, H2A.z antibody, H2A/z antibody, H2A.Z-1 antibody

Database links

Human UniProt/Swiss-Prot:P0C0S5

Protein names

H2AZ, H2A.z, H2A/z, H2A.Z-1

Protein function

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

Protein sequence and domain

Belongs to the histone H2A family.

Protein post-translational modifications

Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.; Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis (By similarity).; Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site.; Not phosphorylated.

Protein cellular localization

Nucleus. Chromosome.

Background

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.

Research area

All research areas>Transcription Regulators>Histone
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize H2AFZ antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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