Rabbit polyclonal HAT1 antibody (A6188)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,ChIP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HAT1 antibody (A6188)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP,ChIP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:50 – 1:200 ChIP 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal HAT1 antibody.

Alternative names:

Check alternative names for the antibody

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KAT1 antibody
HAT 1 antibody|hat1 antibody|HAT1_HUMAN antibody|Histidine aminotransferase 1 antibody|Histone acetyltransferase 1 antibody|Histone acetyltransferase 1 antibody|Histone acetyltransferase type B catalytic subunit antibody|KAT1 antibody|Anti-KAT1 / HAT1 antibody [EPR18775] (ab194296)

SCBT cat No: sc-376268|sc-8752|sc-376200|sc-366092|sc-390562|

Name

Rabbit polyclonal HAT1 antibody

Catalogue No.

A6188

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human HAT1

Host

Rabbit

Applications

WB, IHC, IF, IP, ChIP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:50 – 1:200
ChIP 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 49kDa/Observed: Refer to Figures

Formulation

HAT1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HAT1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

KAT1 antibody

Database links

Human UniProt/Swiss-Prot:O14929

Protein names

KAT1

Protein function

Acetylates soluble but not nucleosomal histone H4 at ‘Lys-5’ (H4K5ac) and ‘Lys-12’ (H4K12ac) and, to a lesser extent, acetylates histone H2A at ‘Lys-5’ (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.

Protein sequence and domain

Belongs to the HAT1 family.

Protein cellular localization

Isoform A: Nucleus matrix.; Isoform B: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Note: Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.

Background

The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene.

Research area

All research areas>Transcription Regulators>HAT1
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize HAT1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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