Rabbit polyclonal HCLS1 antibody (A2165)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HCLS1 antibody (A2165)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal HCLS1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

HS1 antibody, HCLS1 antibody, LckBP1 antibody, p75 antibody, CTTNL antibody
Cortactin like antibody|CTTNL antibody|HCLS 1 antibody|Hcls1 antibody|HCLS1_HUMAN antibody|Hematopoietic cell specific Lyn substrate 1 antibody|Hematopoietic cell-specific LYN substrate 1 antibody|Hematopoietic lineage cell-specific protein antibody|HS 1 antibody|HS1 antibody|LckBP1 antibody|OTTHUMP00000215180 antibody|OTTHUMP00000215182 antibody|p75 antibody|Anti-HCLS1 antibody [EPR16540] (ab202900)

SCBT cat No: sc-135972|sc-28382|sc-1536|

Name

Rabbit polyclonal HCLS1 antibody

Catalogue No.

A2165

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human HCLS1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 54kDa/Observed: Refer to Figures

Formulation

HCLS1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HCLS1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HS1 antibody, HCLS1 antibody, LckBP1 antibody, p75 antibody, CTTNL antibody

Database links

Human UniProt/Swiss-Prot:P14317

Protein names

HS1, HCLS1, LckBP1, p75, CTTNL

Protein function

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.

Protein tissue specificity

Expressed only in tissues and cells of hematopoietic origin.

Protein sequence and domain

Contains 4 cortactin repeats.; Contains 1 SH3 domain.

Protein post-translational modifications

Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES.

Protein cellular localization

Membrane ; Peripheral membrane protein . Cytoplasm . Mitochondrion .

Background

HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin (1,2). HS1 contains four cortactin repeats and a single SH3 domain (2). This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse (3-5). Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCgamma1 (6). HS1 also plays an important role in platelet activation (7).

Research area

All research areas>Signaling Intermediates>Lck BP-1
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize HCLS1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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