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Rabbit polyclonal HDAC7 antibody (A7285)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal HDAC7 antibody.
Check alternative names for the antibodyExpand
HD7A antibody, HDAC7A antibody
DKFZP586J0917 antibody|FLJ99588 antibody|HD 7a antibody|HD7 antibody|HD7a antibody|HDAC 7 antibody|HDAC 7A antibody|Hdac7 antibody|HDAC7_HUMAN antibody|HDAC7A antibody|Histone deacetylase 7 antibody|Histone deacetylase 7A antibody|OTTHUMP00000202813 antibody|OTTHUMP00000202814 antibody|Anti-HDAC7 antibody (ab12174)
SCBT cat No: sc-11421|sc-133106|sc-133225|sc-5250|sc-11419|
Rabbit polyclonal HDAC7 antibody
|Catalogue No.|| |
Human, Mouse, Rat
A synthetic peptide of human HDAC7
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 103kDa/Observed: Refer to figures
HDAC7 antibody was tube-contained.
HDAC7 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
HD7A antibody, HDAC7A antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 .
|Protein sequence and domain|| |
The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.Belongs to the histone deacetylase family. HD type 2 subfamily.
|Protein post-translational modifications|| |
May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181.
|Protein cellular localization|| |
Nucleus. Cytoplasm. Note: In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
AntibodyPlus can customize HDAC7 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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