Rabbit polyclonal HFE2 antibody (A5348)


Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HFE2 antibody (A5348)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody


JH antibody, HJV antibody, RGMC antibody, HFE2A antibody
2310035L15Rik antibody|5230400G09Rik antibody|AI414844 antibody|AI789733 antibody|DL M antibody|Haemojuvelin antibody|HEMOCHROMATOSIS antibody|HEMOCHROMATOSIS DUE TO DEFECT IN HEMOJUVELIN antibody|HEMOCHROMATOSIS DUE TO DEFECT IN HEPCIDIN ANTIMICROBIAL PEPTIDE antibody|HEMOCHROMATOSIS JUVENILE antibody|Hemochromatosis type 2 (juvenile) antibody|Hemochromatosis type 2 antibody|Hemochromatosis type 2 protein antibody|Hemochromatosis type 2 protein homolog antibody|HEMOCHROMATOSIS, TYPE 2A antibody|HEMOCHROMATOSIS, TYPE 2B antibody|Hemojuvelin antibody|HFE 2 antibody|Hfe2 antibody|HFE2A antibody|HJV antibody|JH antibody|Juvenile antibody|MGC23953 antibody|OTTHUMP00000059680 antibody|Repulsive guidance molecule c antibody|RGM C antibody|RGM domain family member C antibody|RGMC antibody|Anti-Repulsive Guidance Molecule C antibody (ab104492)

SCBT cat No: sc-293393|sc-46490|sc-67054|


Rabbit polyclonal HFE2 antibody

Catalogue No.



Human, Mouse, Rat


Recombinant protein of human HFE2





Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200







Molecular weight

Predicted: 45kDa/Observed: Refer to Figures


HFE2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.


HFE2 antibody was purified using affinity purification.


Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

JH antibody, HJV antibody, RGMC antibody, HFE2A antibody

Database links

Human UniProt/Swiss-Prot:Q6ZVN8

Protein names


Protein function

Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.

Protein tissue specificity

Adult and fetal liver, heart, and skeletal muscle.

Protein sequence and domain

Belongs to the repulsive guidance molecule (RGM) family.

Protein post-translational modifications

Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space; regulates HFE2 activity in BMP signaling and thefore iron homeostasis.

Protein cellular localization

Cell membrane ; Lipid-anchor, GPI-anchor . Note: Also released in the extracellular space.


The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.


AntibodyPlus can customize HFE2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody


ABclonal Inc.


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