Rabbit polyclonal HFE2 antibody (A5348)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal HFE2 antibody (A5348)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal HFE2 antibody.

Alternative names:

Check alternative names for the antibody

Expand

JH antibody, HJV antibody, RGMC antibody, HFE2A antibody
2310035L15Rik antibody|5230400G09Rik antibody|AI414844 antibody|AI789733 antibody|DL M antibody|Haemojuvelin antibody|HEMOCHROMATOSIS antibody|HEMOCHROMATOSIS DUE TO DEFECT IN HEMOJUVELIN antibody|HEMOCHROMATOSIS DUE TO DEFECT IN HEPCIDIN ANTIMICROBIAL PEPTIDE antibody|HEMOCHROMATOSIS JUVENILE antibody|Hemochromatosis type 2 (juvenile) antibody|Hemochromatosis type 2 antibody|Hemochromatosis type 2 protein antibody|Hemochromatosis type 2 protein homolog antibody|HEMOCHROMATOSIS, TYPE 2A antibody|HEMOCHROMATOSIS, TYPE 2B antibody|Hemojuvelin antibody|HFE 2 antibody|Hfe2 antibody|HFE2A antibody|HJV antibody|JH antibody|Juvenile antibody|MGC23953 antibody|OTTHUMP00000059680 antibody|Repulsive guidance molecule c antibody|RGM C antibody|RGM domain family member C antibody|RGMC antibody|Anti-Repulsive Guidance Molecule C antibody (ab104492)

SCBT cat No: sc-293393|sc-46490|sc-67054|

Name

Rabbit polyclonal HFE2 antibody

Catalogue No.

A5348

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human HFE2

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 45kDa/Observed: Refer to Figures

Formulation

HFE2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HFE2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

JH antibody, HJV antibody, RGMC antibody, HFE2A antibody

Database links

Human UniProt/Swiss-Prot:Q6ZVN8

Protein names

JH, HJV, RGMC, HFE2A

Protein function

Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.

Protein tissue specificity

Adult and fetal liver, heart, and skeletal muscle.

Protein sequence and domain

Belongs to the repulsive guidance molecule (RGM) family.

Protein post-translational modifications

Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space; regulates HFE2 activity in BMP signaling and thefore iron homeostasis.

Protein cellular localization

Cell membrane ; Lipid-anchor, GPI-anchor . Note: Also released in the extracellular space.

Background

The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Note

AntibodyPlus can customize HFE2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!