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Rabbit polyclonal HIF1AN antibody (A5466)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF,IP,ChIP
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:50 – 1:200 ChIP 1:20 – 1:100
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
DKFZp762F1811 antibody|Factor inhibiting HIF-1 antibody|Factor inhibiting HIF1 antibody|FIH 1 antibody|FIH-1 antibody|FIH1 antibody|FLJ20615 antibody|FLJ22027 antibody|HIF1AN antibody|HIF1N_HUMAN antibody|Hypoxia inducible factor 1 alpha inhibitor antibody|Hypoxia inducible factor 1 alpha subunit inhibitor antibody|Hypoxia inducible factor asparagine hydroxylase antibody|Hypoxia-inducible factor 1-alpha inhibitor antibody|Hypoxia-inducible factor asparagine hydroxylase antibody|Peptide aspartate beta dioxygenase antibody|Anti-HIF1AN antibody [EPR3658] (ab92498)
SCBT cat No: sc-271780|sc-365016|sc-365128|sc-48813|sc-26219|
Rabbit polyclonal HIF1AN antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human HIF1AN
WB, IHC, IF, IP, ChIP
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 40kDa/Observed: Refer to Figures
HIF1AN antibody was tube-contained.
HIF1AN antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Hydroxylates HIF-1 alpha at ‘Asp-803’ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
|Protein sequence and domain|| |
Contains 1 JmjC domain.
|Protein cellular localization|| |
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note: Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.
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|Product type|| |
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