Rabbit polyclonal HIF1AN antibody (A5466)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,ChIP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HIF1AN antibody (A5466)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP,ChIP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200 IP 1:50 – 1:200 ChIP 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

FIH1 antibody
DKFZp762F1811 antibody|Factor inhibiting HIF-1 antibody|Factor inhibiting HIF1 antibody|FIH 1 antibody|FIH-1 antibody|FIH1 antibody|FLJ20615 antibody|FLJ22027 antibody|HIF1AN antibody|HIF1N_HUMAN antibody|Hypoxia inducible factor 1 alpha inhibitor antibody|Hypoxia inducible factor 1 alpha subunit inhibitor antibody|Hypoxia inducible factor asparagine hydroxylase antibody|Hypoxia-inducible factor 1-alpha inhibitor antibody|Hypoxia-inducible factor asparagine hydroxylase antibody|Peptide aspartate beta dioxygenase antibody|Anti-HIF1AN antibody [EPR3658] (ab92498)

SCBT cat No: sc-271780|sc-365016|sc-365128|sc-48813|sc-26219|

Name

Rabbit polyclonal HIF1AN antibody

Catalogue No.

A5466

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human HIF1AN

Host

Rabbit

Applications

WB, IHC, IF, IP, ChIP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200
IP 1:50 – 1:200
ChIP 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 40kDa/Observed: Refer to Figures

Formulation

HIF1AN antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HIF1AN antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

FIH1 antibody

Database links

Human UniProt/Swiss-Prot:Q9NWT6

Protein names

FIH1

Protein function

Hydroxylates HIF-1 alpha at ‘Asp-803’ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

Protein sequence and domain

Contains 1 JmjC domain.

Protein cellular localization

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note: Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.

Note

AntibodyPlus can customize HIF1AN antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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