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Rabbit polyclonal HIP1 antibody (A6921)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal HIP1 antibody.
Check alternative names for the antibodyExpand
HIP-I antibody, ILWEQ antibody
2610109B09Rik antibody|A930014B11Rik antibody|E130315I21Rik antibody|HIP 1 antibody|HIP I antibody|HIP-1 antibody|HIP-I antibody|hip1 antibody|HIP1/PDGFRB fusion gene antibody|HIP1/PDGFRB fusion gene, included antibody|HIP1_HUMAN antibody|HIPI antibody|Huntingtin interacting protein 1 antibody|Huntingtin-interacting protein 1 antibody|Huntingtin-interacting protein I antibody|ILWEQ antibody|KIAA4113 antibody|MGC126506 antibody|MGC27616 antibody|mKIAA4113 antibody|Anti-Huntingtin Interacting Protein HIP1 antibody [EPR10814] (ab181238)
SCBT cat No: sc-136415|sc-47755|sc-135936|sc-47754|sc-271341|
Rabbit polyclonal HIP1 antibody
|Catalogue No.|| |
Recombinant protein of human HIP1
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 116kDa/Observed: Refer to figures
HIP1 antibody was tube-contained.
HIP1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
HIP-I antibody, ILWEQ antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
|Protein tissue specificity|| |
Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
|Protein sequence and domain|| |
The pseudo DED region (pDED) mediates the interaction with IFT57.; Binds F-actin via the talin-like I/LWEQ domain.Belongs to the SLA2 family.; Contains 1 ENTH (epsin N-terminal homology) domain.; Contains 1 I/LWEQ domain.
|Protein cellular localization|| |
Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note: Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington’s disease. Alternative splicing results in multiple transcript variants.
AntibodyPlus can customize HIP1 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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