Rabbit polyclonal HIP1 antibody (A6921)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HIP1 antibody (A6921)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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HIP-I antibody, ILWEQ antibody
2610109B09Rik antibody|A930014B11Rik antibody|E130315I21Rik antibody|HIP 1 antibody|HIP I antibody|HIP-1 antibody|HIP-I antibody|hip1 antibody|HIP1/PDGFRB fusion gene antibody|HIP1/PDGFRB fusion gene, included antibody|HIP1_HUMAN antibody|HIPI antibody|Huntingtin interacting protein 1 antibody|Huntingtin-interacting protein 1 antibody|Huntingtin-interacting protein I antibody|ILWEQ antibody|KIAA4113 antibody|MGC126506 antibody|MGC27616 antibody|mKIAA4113 antibody|Anti-Huntingtin Interacting Protein HIP1 antibody [EPR10814] (ab181238)

SCBT cat No: sc-136415|sc-47755|sc-135936|sc-47754|sc-271341|

Name

Rabbit polyclonal HIP1 antibody

Catalogue No.

A6921

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human HIP1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 116kDa/Observed: Refer to figures

Formulation

HIP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HIP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

HIP-I antibody, ILWEQ antibody

Database links

Human UniProt/Swiss-Prot:O00291

Protein names

HIP-I, ILWEQ

Protein function

Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.

Protein tissue specificity

Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.

Protein sequence and domain

The pseudo DED region (pDED) mediates the interaction with IFT57.; Binds F-actin via the talin-like I/LWEQ domain.Belongs to the SLA2 family.; Contains 1 ENTH (epsin N-terminal homology) domain.; Contains 1 I/LWEQ domain.

Protein cellular localization

Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note: Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.

Background

The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington’s disease. Alternative splicing results in multiple transcript variants.

Note

AntibodyPlus can customize HIP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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