Rabbit polyclonal HIRA antibody (A8461)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal HIRA antibody (A8461)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal HIRA antibody.

Alternative names:

Check alternative names for the antibody

Expand

TUP1 antibody, DGCR1 antibody, TUPLE1 antibody
DGCR1 antibody|DiGeorge critical region gene 1 antibody|HIR antibody|HIR histone cell cycle regulation defective homolog A antibody|HIRA antibody|HIRA protein antibody|HIRA_HUMAN antibody|Histone cell cycle regulator antibody|Protein HIRA antibody|TUP 1 antibody|TUP1 like enhancer of split protein 1 antibody|TUP1-like enhancer of split protein 1 antibody|TUPLE1 antibody|Anti-HIRA antibody (ab20655)

SCBT cat No: sc-130636|sc-48774|

Name

Rabbit polyclonal HIRA antibody

Catalogue No.

A8461

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human HIRA

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:100 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 112kDa/Observed: Refer to figures

Formulation

HIRA antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

HIRA antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

TUP1 antibody, DGCR1 antibody, TUPLE1 antibody

Database links

Human UniProt/Swiss-Prot:P54198

Protein names

TUP1, DGCR1, TUPLE1

Protein function

Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Protein tissue specificity

Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.

Protein sequence and domain

Belongs to the WD repeat HIR1 family.; Contains 7 WD repeats.

Protein post-translational modifications

Sumoylated.; Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo.

Protein cellular localization

Nucleus. Nucleus, PML body. Note: Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.

Background

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Research area

All research areas>Cell Cycle Proteins>HIRA
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize HIRA antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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