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Rabbit polyclonal HIRIP3 antibody (A7014)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100
Recommended protocols: check protocols
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SCBT cat No:
Rabbit polyclonal HIRIP3 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human HIRIP3
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 62kDa/Observed: Refer to figures
HIRIP3 antibody was tube-contained.
HIRIP3 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.
|Protein tissue specificity|| |
Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart.
|Protein post-translational modifications|| |
Phosphorylated by CK2.
|Protein cellular localization|| |
Nucleus . Note: Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis.
The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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|Product type|| |
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